Association of latent autoimmune diabetes of adults with type 3 polyglandular autoimmune syndrome-a diagnostic challenge.

Autor: Rehman UL; Department of Endocrinology, Ali Medical, Islamabad, Pakistan., Hamza HM; 4th Year MBBS Student, School of Medicine, Foundation University School of Health Sciences, Islamabad, Pakistan., Malik MM; 4th Year MBBS Student, Foundation University School of Health Sciences, Islamabad, Pakistan., Awan AA; 4th Year MBBS Student, School of Medicine, Foundation University School of Health Sciences, Islamabad, Pakistan.
Jazyk: angličtina
Zdroj: JPMA. The Journal of the Pakistan Medical Association [J Pak Med Assoc] 2024 May; Vol. 74 (5), pp. 990-992.
DOI: 10.47391/JPMA.10108
Abstrakt: Autoimmune polyendocrine syndromes (APS) encompass m ultiple e ndocrin e gland ins ufficiencies asso ci ated wit h auto immune disease. This c as e report underscores the importance of recognising the association between latent auto immune di a betes of ad ults (LADA) and type 3 polyglandular syndrome. A 42-year-old man belonging to R awalpi ndi, Pakistan, p resented to th e out patient department (OPD) of Ali Medi cal Centre, Islamab ad, i n Januar y 2023 with the complaints o f e xtreme thirs t and frequent urination. The patient reported consistently raised app etite an d eating four to five meals a day along with abrupt weight loss, dry mouth, fatigue occasional dizziness, an d dyspnoea. He was diagno s ed with type 3 polygla ndular syndrome w ith associat io n of LADA. Daily administration of 10 units of glargine insulin, along with six units of rapid-acting insulin, was prescribed. The patient's H bA1c level reduce d in a few months afte r succe ssive follow-up. Patients who exhi bit uncontrol led diabe tes despite dietar y and oral hypoglycaemic management should be further investigated for multiple au toimmune endocrine disorders.
Databáze: MEDLINE