Adding intrinsically disordered proteins to biological ageing clocks.

Autor: Dormann D; Biocenter, Johannes Gutenberg University, Mainz, Germany. ddormann@uni-mainz.de.; Institute for Molecular Biology, Mainz, Germany. ddormann@uni-mainz.de., Lemke EA; Biocenter, Johannes Gutenberg University, Mainz, Germany. edlemke@uni-mainz.de.; Institute for Molecular Biology, Mainz, Germany. edlemke@uni-mainz.de.; Institute for Quantitative and Computational Biosciences, Johannes Gutenberg University, Mainz, Germany. edlemke@uni-mainz.de.
Jazyk: angličtina
Zdroj: Nature cell biology [Nat Cell Biol] 2024 Jun; Vol. 26 (6), pp. 851-858. Date of Electronic Publication: 2024 May 23.
DOI: 10.1038/s41556-024-01423-w
Abstrakt: Research into how the young and old differ, and which biomarkers reflect the diverse biological processes underlying ageing, is a current and fast-growing field. Biological clocks provide a means to evaluate whether a molecule, cell, tissue or even an entire organism is old or young. Here we summarize established and emerging molecular clocks as timepieces. We emphasize that intrinsically disordered proteins (IDPs) tend to transform into a β-sheet-rich aggregated state and accumulate in non-dividing or slowly dividing cells as they age. We hypothesize that understanding these protein-based molecular ageing mechanisms might provide a conceptual pathway to determining a cell's health age by probing the aggregation state of IDPs, which we term the IDP clock.
(© 2024. Springer Nature Limited.)
Databáze: MEDLINE
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