Clinical implications of brain asymmetries.

Autor: Ocklenburg S; Department of Psychology, MSH Medical School Hamburg, Hamburg, Germany. sebastian.ocklenburg@medicalschool-hamburg.de.; ICAN Institute for Cognitive and Affective Neuroscience, MSH Medical School Hamburg, Hamburg, Germany. sebastian.ocklenburg@medicalschool-hamburg.de.; Biopsychology, Institute of Cognitive Neuroscience, Faculty of Psychology, Ruhr University Bochum, Bochum, Germany. sebastian.ocklenburg@medicalschool-hamburg.de., Mundorf A; ISM Institute for Systems Medicine and Department of Human Medicine, MSH Medical School Hamburg, Hamburg, Germany.; Division of Cognitive Neuroscience, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Gerrits R; Department of Experimental-Clinical and Health Psychology, Ghent University, Ghent, Belgium.; Ghent Institute for Functional and Metabolic Imaging (GIfMI), Ghent University, Ghent, Belgium., Karlsson EM; Department of Experimental-Clinical and Health Psychology, Ghent University, Ghent, Belgium.; Ghent Institute for Functional and Metabolic Imaging (GIfMI), Ghent University, Ghent, Belgium., Papadatou-Pastou M; National and Kapodistrian University of Athens, Athens, Greece.; Biomedical Research Foundation, Academy of Athens, Athens, Greece., Vingerhoets G; Department of Experimental-Clinical and Health Psychology, Ghent University, Ghent, Belgium.; Ghent Institute for Functional and Metabolic Imaging (GIfMI), Ghent University, Ghent, Belgium.
Jazyk: angličtina
Zdroj: Nature reviews. Neurology [Nat Rev Neurol] 2024 Jul; Vol. 20 (7), pp. 383-394. Date of Electronic Publication: 2024 May 23.
DOI: 10.1038/s41582-024-00974-8
Abstrakt: No two human brains are alike, and with the rise of precision medicine in neurology, we are seeing an increased emphasis on understanding the individual variability in brain structure and function that renders every brain unique. Functional and structural brain asymmetries are a fundamental principle of brain organization, and recent research suggests substantial individual variability in these asymmetries that needs to be considered in clinical practice. In this Review, we provide an overview of brain asymmetries, variations in such asymmetries and their relevance in the clinical context. We review recent findings on brain asymmetries in neuropsychiatric and neurodevelopmental disorders, as well as in specific learning disabilities, with an emphasis on large-scale database studies and meta-analyses. We also highlight the relevance of asymmetries for disease symptom onset in neurodegenerative diseases and their implications for lateralized treatments, including brain stimulation. We conclude that alterations in brain asymmetry are not sufficiently specific to act as diagnostic biomarkers but can serve as meaningful symptom or treatment response biomarkers in certain contexts. On the basis of these insights, we provide several recommendations for neurological clinical practice.
(© 2024. Springer Nature Limited.)
Databáze: MEDLINE
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