Comparing the in vitro efficacy of chlorhexidine and povidone-iodine in the prevention of post-surgical endophthalmitis.

Autor: Batista CSP; Microbiology department, Hospital de la Santa Creu i Sant Pau, C/ Sant Quintí, 89. Planta B-2, Barcelona, 08041, Spain.; Department of Genetics and Microbiology, Autonomous University of Barcelona, Barcelona, Spain., Loscos-Giménez I; Ophthalmology department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Gámez M; Pharmacy department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Altaba R; Microbiology department, Hospital de la Santa Creu i Sant Pau, C/ Sant Quintí, 89. Planta B-2, Barcelona, 08041, Spain., de Miniac D; Microbiology department, Hospital de la Santa Creu i Sant Pau, C/ Sant Quintí, 89. Planta B-2, Barcelona, 08041, Spain., Martí N; Microbiology department, Hospital de la Santa Creu i Sant Pau, C/ Sant Quintí, 89. Planta B-2, Barcelona, 08041, Spain., Bassaganyas F; Ophthalmology department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Juanes E; Pharmacy department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.; Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain., Rivera A; Microbiology department, Hospital de la Santa Creu i Sant Pau, C/ Sant Quintí, 89. Planta B-2, Barcelona, 08041, Spain. mrivera@santpau.cat.; Department of Genetics and Microbiology, Autonomous University of Barcelona, Barcelona, Spain. mrivera@santpau.cat.; Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain. mrivera@santpau.cat., Navarro F; Microbiology department, Hospital de la Santa Creu i Sant Pau, C/ Sant Quintí, 89. Planta B-2, Barcelona, 08041, Spain.; Department of Genetics and Microbiology, Autonomous University of Barcelona, Barcelona, Spain.; Sant Pau Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain.
Jazyk: angličtina
Zdroj: Journal of ophthalmic inflammation and infection [J Ophthalmic Inflamm Infect] 2024 May 23; Vol. 14 (1), pp. 20. Date of Electronic Publication: 2024 May 23.
DOI: 10.1186/s12348-024-00404-2
Abstrakt: Background: Intravitreal injections are a common ophthalmologic procedure. While infections following these injections are rare, they can lead to endophthalmitis, with potentially serious consequences. Various methods have been proposed to prevent endophthalmitis, including the use of antisepsis and antibiotics in patient preparation.
Purpose: To evaluate the antiseptic efficacy of aqueous chlorhexidine (CHX) and povidone-iodine (PI) when used alone and in combination with lidocaine gel (LG) in vitro.
Methods: Two independent experimental trials were conducted. The first trial determined the minimum inhibitory concentrations (MICs) and the minimum bactericidal concentrations (MBCs) of CHX and PI against six bacterial strains. The second trial evaluated the bactericidal efficacy of the antiseptic agents (CHX 0.1% and PI 5%) and their combination with LG against the same bacterial strains.
Results: CHX was more effective than PI in reducing the number of colonies forming units (cfus) of the tested bacteria. The order in which the antiseptic and LG were administered affected their effectiveness, with CHX administered before LG resulting in greater reduction of bacterial growth.
Conclusions: CHX 0.1% is more effective than PI 5% as an antiseptic agent. Application of CHX and PI prior to the use of lidocaine gel results in a more effective reduction of microorganisms.
(© 2024. The Author(s).)
Databáze: MEDLINE
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