Differentiating Low-Grade from High-Grade Intracranial Ependymomas: Comparison of Dynamic Contrast-Enhanced MRI and Diffusion-Weighted Imaging.

Autor: Arevalo-Perez J; From the Department of Radiology (J.A.-P., E.Y.-C., V.H., O.Y., A.I.H.), Memorial Sloan Kettering Cancer Center, New York, New York arevalj1@mskcc.org., Yllera-Contreras E; From the Department of Radiology (J.A.-P., E.Y.-C., V.H., O.Y., A.I.H.), Memorial Sloan Kettering Cancer Center, New York, New York., Peck KK; Department of Medical Physics (K.K.P.), Memorial Sloan Kettering Cancer Center, New York, New York., Hatzoglou V; From the Department of Radiology (J.A.-P., E.Y.-C., V.H., O.Y., A.I.H.), Memorial Sloan Kettering Cancer Center, New York, New York., Yildirim O; From the Department of Radiology (J.A.-P., E.Y.-C., V.H., O.Y., A.I.H.), Memorial Sloan Kettering Cancer Center, New York, New York., Rosenblum MK; Department of Pathology (M.K.R.), Memorial Sloan Kettering Cancer Center, New York, New York., Holodny AI; From the Department of Radiology (J.A.-P., E.Y.-C., V.H., O.Y., A.I.H.), Memorial Sloan Kettering Cancer Center, New York, New York.
Jazyk: angličtina
Zdroj: AJNR. American journal of neuroradiology [AJNR Am J Neuroradiol] 2024 Jul 08; Vol. 45 (7), pp. 927-933. Date of Electronic Publication: 2024 Jul 08.
DOI: 10.3174/ajnr.A8226
Abstrakt: Background and Purpose: The aim of this study was to determine the diagnostic value of fractional plasma volume derived from dynamic contrast-enhanced perfusion MR imaging versus ADC, obtained from DWI in differentiating between grade 2 (low-grade) and grade 3 (high-grade) intracranial ependymomas.
Materials and Methods: A hospital database was created for the period from January 2013 through June 2022, including patients with histologically-proved ependymoma diagnosis with available dynamic contrast-enhanced MR imaging. Both dynamic contrast-enhanced perfusion and DWI were performed on each patient using 1.5T and 3T scanners. Fractional plasma volume maps and ADC maps were calculated. ROIs were defined by a senior neuroradiologist manually by including the enhancing tumor on every section and conforming a VOI to obtain the maximum value of fractional plasma volume (Vp max ) and the minimum value of ADC (ADC min ). A Mann-Whitney U test at a significance level of corrected P  = .01 was used to evaluate the differences. Additionally, receiver operating characteristic curve analysis was applied to assess the sensitivity and specificity of Vp max and ADC min values.
Results: A total of 20 patients with ependymomas (10 grade 2 tumors and 10 grade 3 tumors) were included. Vp max values for grade 3 ependymomas were significantly higher ( P  < .002) than those for grade 2. ADC min values were overall lower in high-grade lesions. However, no statistically significant differences were found ( P  = .12114).
Conclusions: As a dynamic contrast-enhanced perfusion MR imaging metric, fractional plasma volume can be used as an indicator to differentiate grade 2 and grade 3 ependymomas. Dynamic contrast-enhanced perfusion MR imaging plays an important role with high diagnostic value in differentiating low- and high-grade ependymoma.
(© 2024 by American Journal of Neuroradiology.)
Databáze: MEDLINE
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