Concordance between CDKN2A homozygous deletion and MTAP immunohistochemical loss in fluoroedenite-induced pleural mesothelioma: An immunohistochemical and molecular study on a single-institution series.

Autor: Broggi G; Department of Medical, Surgical Sciences and Advanced Technologies 'G.F. Ingrassia', Anatomic Pathology, University of Catania, Catania 95123, Italy. Electronic address: giuseppe.broggi@phd.unict.it., Massimino M; Department of Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy; Center of Experimental Oncology and Hematology, A.O.U. Policlinico 'G. Rodolico-S. Marco', Catania, Italy., Failla M; Department of Medical, Surgical Sciences and Advanced Technologies 'G.F. Ingrassia', Anatomic Pathology, University of Catania, Catania 95123, Italy., Filetti V; Department of Clinical and Experimental Medicine, Section of Occupational Medicine, University of Catania, Catania, Italy., Rapisarda V; Department of Clinical and Experimental Medicine, Section of Occupational Medicine, University of Catania, Catania, Italy., Ledda C; Department of Clinical and Experimental Medicine, Section of Occupational Medicine, University of Catania, Catania, Italy., Lombardo C; Human Anatomy and Histology, Department of Medical and Surgical Sciences and Advanced Technologies, University of Catania, Catania, Italy., Loreto C; Human Anatomy and Histology, Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy., Vigneri P; Medical Oncology Unit, Humanitas istituto Clinico Catanese, Catania, Italy; Department of Clinical and Experimental Medicine, University of Catania, Catania 95123, Italy., Caltabiano R; Department of Medical, Surgical Sciences and Advanced Technologies 'G.F. Ingrassia', Anatomic Pathology, University of Catania, Catania 95123, Italy.
Jazyk: angličtina
Zdroj: Pathology, research and practice [Pathol Res Pract] 2024 Jul; Vol. 259, pp. 155350. Date of Electronic Publication: 2024 May 14.
DOI: 10.1016/j.prp.2024.155350
Abstrakt: Fluoroedenite-induced pleural mesothelioma (FE-induced-PM) is a rare and small subset of PM that shares with its asbestos-induced counterpart the same aggressive biological behavior and poor prognosis, but that differs from it from a pathogenetic point of view as it is associated with exposure to fluoroedenite, a carcinogenic agent that shows similarities with tremolite amphibolic asbestos fibers. Although it has been demonstrated that asbestos-induced PMs frequently harbor CDKN2A homozygous deletion and that the immunohistochemical loss of MTAP may represent a cheap and reliable surrogate marker for this molecular alteration, little is known about the molecular landscape and the reliability of MTAP immunohistochemistry in this peculiar subset of PM. The study herein presented investigated the prevalence of CDKN2A homozygous deletion and its concordance with MTAP immunohistochemical status on a cohort of 10 cases of FE-induced-PM from patients with environmental exposure to FE fibers, who were residents in the small town of Biancavilla (Sicily, Italy) or nearby areas. CDKN2A homozygous deletions were found in 3 out of 10 cases (30%) and all these cases showed concomitant cytoplasmic loss of MTAP with a concordance rate of 100%. Despite the relatively low number of cases included in our series, MTAP immunohistochemistry seemed to represent a reliable immunohistochemical surrogate marker of CDKNA homozygous deletion even in this subset of PMs.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier GmbH.. All rights reserved.)
Databáze: MEDLINE
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