Designing and Synthesis of Novel Fexofenadine-Derived Hydrazone-Schiff Bases as Potential Urease Inhibitors: In-Vitro, Molecular Docking and DFT Investigations.
| Autor: | Ayaz M; Department of Chemistry, University of Malakand, P.O. Box, 18800, Dir, Lower, Pakistan., Alam A; Department of Chemistry, University of Malakand, P.O. Box, 18800, Dir, Lower, Pakistan., Zainab; College of Chemistry and Materials Science, Hebei Normal University, Shijiazhuang, 050024, China., Elhenawy AA; Chemistry Department, Faculty of Science, Al-Azhar University, Cairo, Egypt., Ur Rehman N; Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, 616, Oman., Ur Rahman S; Department of Chemistry, University of Malakand, P.O. Box, 18800, Dir, Lower, Pakistan., Ali M; Department of Chemistry, University of Malakand, P.O. Box, 18800, Dir, Lower, Pakistan., Latif A; Department of Chemistry, University of Malakand, P.O. Box, 18800, Dir, Lower, Pakistan., Al-Harrasi A; Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, 616, Oman., Ahmad M; Department of Chemistry, University of Malakand, P.O. Box, 18800, Dir, Lower, Pakistan. |
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| Jazyk: | angličtina |
| Zdroj: | Chemistry & biodiversity [Chem Biodivers] 2024 Aug; Vol. 21 (8), pp. e202400704. Date of Electronic Publication: 2024 Jul 06. |
| DOI: | 10.1002/cbdv.202400704 |
| Abstrakt: | Thirteen novel hydrazone-Schiff bases (3-15) of fexofenadine were succesfully synthesized, structurally deduced and finally assessed their capability to inhibit urease enzyme (in vitro). In the series, six compounds 12 (IC (© 2024 Wiley-VHCA AG, Zurich, Switzerland.) |
| Databáze: | MEDLINE |
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