Subclinical choroidal involvement in Systemic Lupus Erythematosus.

Autor: Ferreira A; Department of Ophthalmology, Centro Hospitalar Universitário de Santo António, Porto, Portugal. andre.ferreira@live.com.pt.; Department of Biomedicine - Unit of Anatomy, Faculty of Medicine of University of Porto, Porto, Portugal. andre.ferreira@live.com.pt.; Centre for Health Technology and Services Research, Health Research Network (CINTESIS@RISE), Faculty of Medicine of the University of Porto, Porto, Portugal. andre.ferreira@live.com.pt., Viveiros L; Serviço de Medicina Interna, Centro Hospitalar Universitário de Santo António, Porto, Portugal., Faria R; Unidade de Imunologia Clínica, Centro Hospitalar Universitário de Santo António, Porto, Portugal.; Unidade Multidisciplinar de Investigação Biomédica, Instituto de Ciências Biomédicas Abel Salazar, Universidade Do Porto, Porto, Portugal., Abreu AC; Department of Ophthalmology, Centro Hospitalar Universitário de Santo António, Porto, Portugal., Santos D; Department of Ophthalmology, Centro Hospitalar Universitário de Santo António, Porto, Portugal., Furtado MJ; Department of Ophthalmology, Centro Hospitalar Universitário de Santo António, Porto, Portugal.; Unidade Multidisciplinar de Investigação Biomédica, Instituto de Ciências Biomédicas Abel Salazar, Universidade Do Porto, Porto, Portugal., Lume M; Department of Ophthalmology, Centro Hospitalar Universitário de Santo António, Porto, Portugal., Andrade JP; Department of Biomedicine - Unit of Anatomy, Faculty of Medicine of University of Porto, Porto, Portugal.; Centre for Health Technology and Services Research, Health Research Network (CINTESIS@RISE), Faculty of Medicine of the University of Porto, Porto, Portugal., Menéres P; Department of Ophthalmology, Centro Hospitalar Universitário de Santo António, Porto, Portugal.; Department of Ophthalmology, Instituto de Ciência Biomédicas Abel Salazar, Universidade Do Porto, Porto, Portugal.
Jazyk: angličtina
Zdroj: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie [Graefes Arch Clin Exp Ophthalmol] 2024 Oct; Vol. 262 (10), pp. 3313-3321. Date of Electronic Publication: 2024 May 23.
DOI: 10.1007/s00417-024-06526-6
Abstrakt: Purpose: To assess the choroidal status of Systemic Lupus Erythematosus (SLE) patients using Optical Coherence Tomography (OCT) and OCT-Angiography.
Methods: SLE patients with disease duration < 10 years, no disease activity and no ocular involvement were recruited and cross-sectionally evaluated. A demographically similar cohort of healthy subjects was used for comparison. The main outcome is choroidal vascularity index (CVI). As secondary outcomes, choriocapillaris parameters and choroidal thickness (CT) were evaluated.
Results: Forty eyes of 40 subjects (20 SLE patients and 20 healthy subjects) were studied with a mean ± SD age of 36.7 ± 9.9 years. In the SLE group, the mean ± SD duration of disease was 7.35 ± 2.21 years. Increased CVI was found in the SLE group (p = 0.022). Considering the choriocapillaris, SLE patients presented a lower number (p = 0.037) and a smaller total area (p = 0.041) of signal voids. No differences between groups were found in CT. For SLE patients, CT at subfoveal, temporal and inferior locations presented a negative moderate correlation with disease duration. A strong correlation between choriocapillaris parameters and age was demonstrated for both groups.
Conclusions: This study provides evidence of subclinical choroidal changes in adult SLE patients with inactive disease and no overt ocular manifestation. Increased CVI and fewer and smaller flow voids in choriocapillaris with normal CT suggest increased choroidal vascularity in SLE.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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