Grey Matter Atrophy and its Relationship with White Matter Lesions in Patients with Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease, Aquaporin-4 Antibody-Positive Neuromyelitis Optica Spectrum Disorder, and Multiple Sclerosis.

Autor:	Cortese R; Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.; Queen Square MS Center, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK., Battaglini M; Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.; SIENA imaging SRL, Siena, Italy., Prados F; Queen Square MS Center, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.; Center for Medical Imaging Computing, Medical Physics, and Biomedical Engineering, UCL, London, UK.; E-Health Center University Oberta de Catalunya, Barcelona, Spain., Gentile G; Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.; SIENA imaging SRL, Siena, Italy., Luchetti L; Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.; SIENA imaging SRL, Siena, Italy., Bianchi A; Queen Square MS Center, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK., Haider L; Queen Square MS Center, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK., Jacob A; NMO Clinical Service at the Walton Centre, Liverpool, UK.; Department of Neurology, Cleveland Clinic, Abu Dhabi, UAE., Palace J; Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK., Messina S; Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK., Paul F; Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charité-Universitaetsmedizin Berlin, Berlin, Germany., Marignier R; Department of Neurology, Multiple Sclerosis, Myelin Disorders, and Neuro-inflammation, Pierre Wertheimer Neurological Hospital, Hospices Civils de Lyon, Lyon, France., Durand-Dubief F; Department of Neurology, Multiple Sclerosis, Myelin Disorders, and Neuro-inflammation, Pierre Wertheimer Neurological Hospital, Hospices Civils de Lyon, Lyon, France., de Medeiros Rimkus C; Department of Radiology and Oncology, Faculty of Medicine, University of São Paulo (FMUSP), São Paulo, Brazil., Apostolos Pereira SL; Department of Neurology, Faculty of Medicine, University of São Paulo (FMUSP), São Paulo, Brazil., Sato DK; Pontifical Catholic University of Rio Grande do Sul (PUCRS), School of Medicine, Porto Alegre, Brazil., Filippi M; Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Neurorehabilitation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Neurophysiology Service, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Rocca MA; Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Cacciaguerra L; Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.; Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Rovira À; Section of Neuroradiology, Department of Radiology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain., Sastre-Garriga J; Multiple Sclerosis Centre of Catalonia (Cemcat), Department of Neurology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain., Arrambide G; Multiple Sclerosis Centre of Catalonia (Cemcat), Department of Neurology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain., Liu Y; Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China., Duan Y; Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China., Gasperini C; Department of Neurosciences, S. Camillo-Forlanini Hospital, Rome, Italy., Tortorella C; Department of Neurosciences, S. Camillo-Forlanini Hospital, Rome, Italy., Ruggieri S; Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.; Neuroimmunology Unit, IRCSS Fondazione Santa Lucia, Rome, Italy., Amato MP; Department Neurofarba, University of Florence, Florence, Italy.; IRCCS Don Carlo Gnocchi Foundation, Florence, Italy., Ulivelli M; Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy., Groppa S; Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Grothe M; Department of Neurology, University Medicine of Greifswald, Greifswald, Germany., Llufriu S; Service of Neurology, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Center of Neuroimmunology, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), and Universitat de Barcelona, Barcelona, Spain., Sepulveda M; Service of Neurology, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Center of Neuroimmunology, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), and Universitat de Barcelona, Barcelona, Spain., Lukas C; Institute of Neuroradiology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.; Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany., Bellenberg B; Institute of Neuroradiology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany., Schneider R; Institute of Neuroradiology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.; Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany., Sowa P; Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway., Celius EG; Department of Neurology, Oslo University Hospital and Faculty of Medicine, University of Oslo, Oslo, Norway., Pröbstel AK; Department of Neurology, Biomedicine and Clinical Research, and Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital and University of Basel, Basel, Switzerland., Granziera C; Department of Neurology, Biomedicine and Clinical Research, and Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital and University of Basel, Basel, Switzerland.; Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland., Yaldizli Ö; Department of Neurology, Biomedicine and Clinical Research, and Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital and University of Basel, Basel, Switzerland., Müller J; Department of Neurology, Biomedicine and Clinical Research, and Research Center for Clinical Neuroimmunology and Neuroscience Basel, University Hospital and University of Basel, Basel, Switzerland.; Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland., Stankoff B; Sorbonne University, Paris Brain Institute, ICM, Pitié Salpêtrière Hospital, Paris, France., Bodini B; Sorbonne University, Paris Brain Institute, ICM, Pitié Salpêtrière Hospital, Paris, France., Barkhof F; Center for Medical Imaging Computing, Medical Physics, and Biomedical Engineering, UCL, London, UK.; Radiology & Nuclear medicine, VU University Medical Center, Amsterdam, The Netherlands., Ciccarelli O; Queen Square MS Center, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.; National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Center, London, UK., De Stefano N; Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
Jazyk:	angličtina
Zdroj:	Annals of neurology [Ann Neurol] 2024 Aug; Vol. 96 (2), pp. 276-288. Date of Electronic Publication: 2024 May 23.
DOI:	10.1002/ana.26951
Abstrakt:	Objective: To evaluate: (1) the distribution of gray matter (GM) atrophy in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4+NMOSD), and relapsing-remitting multiple sclerosis (RRMS); and (2) the relationship between GM volumes and white matter lesions in various brain regions within each disease. Methods: A retrospective, multicenter analysis of magnetic resonance imaging data included patients with MOGAD/AQP4+NMOSD/RRMS in non-acute disease stage. Voxel-wise analyses and general linear models were used to evaluate the relevance of regional GM atrophy. For significant results (p < 0.05), volumes of atrophic areas are reported. Results: We studied 135 MOGAD patients, 135 AQP4+NMOSD, 175 RRMS, and 144 healthy controls (HC). Compared with HC, MOGAD showed lower GM volumes in the temporal lobes, deep GM, insula, and cingulate cortex (75.79 cm 3 ); AQP4+NMOSD in the occipital cortex (32.83 cm 3 ); and RRMS diffusely in the GM (260.61 cm 3 ). MOGAD showed more pronounced temporal cortex atrophy than RRMS (6.71 cm 3 ), whereas AQP4+NMOSD displayed greater occipital cortex atrophy than RRMS (19.82 cm 3 ). RRMS demonstrated more pronounced deep GM atrophy in comparison with MOGAD (27.90 cm 3 ) and AQP4+NMOSD (47.04 cm 3 ). In MOGAD, higher periventricular and cortical/juxtacortical lesions were linked to reduced temporal cortex, deep GM, and insula volumes. In RRMS, the diffuse GM atrophy was associated with lesions in all locations. AQP4+NMOSD showed no lesion/GM volume correlation. Interpretation: GM atrophy is more widespread in RRMS compared with the other two conditions. MOGAD primarily affects the temporal cortex, whereas AQP4+NMOSD mainly involves the occipital cortex. In MOGAD and RRMS, lesion-related tract degeneration is associated with atrophy, but this link is absent in AQP4+NMOSD. ANN NEUROL 2024;96:276-288. (© 2024 The Author(s). Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.)
Databáze:	MEDLINE
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