Coordinating mitochondrial translation with assembly of the OXPHOS complexes.
| Autor: | Kremer LS; Department of Cellular Biochemistry, University Medical Center Göttingen, Humboldtallee 23, Göttingen 37073, Germany., Rehling P; Department of Cellular Biochemistry, University Medical Center Göttingen, Humboldtallee 23, Göttingen 37073, Germany.; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Robert-Koch-Str. 40, Göttingen 37075, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology, Translational Neuroinflammation and Automated Microscopy, Robert-Koch-Str. 40, Göttingen 37075, Germany.; Max Planck Institute for Multidisciplinary Science, Am Faßberg 11, Göttingen 37077, Germany. |
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| Jazyk: | angličtina |
| Zdroj: | Human molecular genetics [Hum Mol Genet] 2024 May 22; Vol. 33 (R1), pp. R47-R52. |
| DOI: | 10.1093/hmg/ddae025 |
| Abstrakt: | The mitochondrial oxidative phosphorylation (OXPHOS) system produces the majority of energy required by cells. Given the mitochondrion's endosymbiotic origin, the OXPHOS machinery is still under dual genetic control where most OXPHOS subunits are encoded by the nuclear DNA and imported into mitochondria, while a small subset is encoded on the mitochondrion's own genome, the mitochondrial DNA (mtDNA). The nuclear and mtDNA encoded subunits must be expressed and assembled in a highly orchestrated fashion to form a functional OXPHOS system and meanwhile prevent the generation of any harmful assembly intermediates. While several mechanisms have evolved in eukaryotes to achieve such a coordinated expression, this review will focus on how the translation of mtDNA encoded OXPHOS subunits is tailored to OXPHOS assembly. (© The Author(s) 2024. Published by Oxford University Press.) |
| Databáze: | MEDLINE |
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