Antimicrobial resistance among common bacterial pathogens in Indonesia: a systematic review.

Autor:	Gach MW; Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia., Lazarus G; Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia., Simadibrata DM; Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA., Sinto R; Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Internal Medicine, Division of Tropical Medicine and Infectious Diseases, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia., Saharman YR; Department of Clinical Microbiology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia., Limato R; Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Nelwan EJ; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.; Department of Internal Medicine, Division of Tropical Medicine and Infectious Diseases, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia., van Doorn HR; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford University Clinical Research Unit, Hanoi, Vietnam., Karuniawati A; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.; Department of Clinical Microbiology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia., Hamers RL; Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Jazyk:	angličtina
Zdroj:	The Lancet regional health. Southeast Asia [Lancet Reg Health Southeast Asia] 2024 May 13; Vol. 26, pp. 100414. Date of Electronic Publication: 2024 May 13 (Print Publication: 2024).
DOI:	10.1016/j.lansea.2024.100414
Abstrakt:	Background: The WHO Global Antimicrobial Resistance Surveillance System (GLASS) aims to describe antimicrobial resistance (AMR) patterns and trends in common bacterial pathogens, but data remain limited in many low and middle-income countries including Indonesia. Methods: We systematically searched Embase, PubMed and Global Health Database and three Indonesian databases for original peer-reviewed articles in English and Indonesian, published between January 1, 2000 and May 25, 2023, that reported antimicrobial susceptibility for the 12 GLASS target pathogens from human samples. Pooled AMR prevalence estimates were calculated for relevant pathogen-antimicrobial combinations accounting for the sampling weights of the studies (PROSPERO: CRD42019155379). Findings: Of 2182 search hits, we included 102 papers, comprising 19,517 bacterial isolates from hospitals (13,647) and communities (5870). In hospital settings, 21.6% of Klebsiella pneumoniae isolates, 18.3% of Escherichia coli isolates, 35.8% of Pseudomonas aeruginosa isolates and 70.7% of Acinetobacter baumannii isolates were carbapenem-resistant; 29.9% of Streptococcus pneumoniae isolates were penicillin-resistant; and 22.2% of Staphylococcus aureus isolates were methicillin-resistant. Hospital prevalence of carbapenem-resistant K. pneumoniae and E. coli , and penicillin-resistant S. pneumoniae increased over time. In communities, 28.3% of K. pneumoniae isolates and 15.7% of E. coli isolates were carbapenem-resistant, 23.9% of S. pneumoniae isolates were penicillin-resistant, and 11.1% of S. aureus isolates were methicillin-resistant. Data were limited for the other pathogens. Interpretation: AMR prevalence estimates were high for critical gram-negative bacteria. However, data were insufficient to draw robust conclusions about the full contemporary AMR situation in Indonesia. Implementation of national AMR surveillance is a priority to address these gaps and inform context-specific interventions. Funding: Wellcome Africa Asia Programme Vietnam. Competing Interests: HRVD serves as Board Member of The Wellcome Surveillance and Epidemiology of Drug-resistant Infections Consortium (SEDRIC). AK serves as the current Chair of the National AMR Committee (Komite Pengendalian Resistensi Antimikroba). The other authors declare no competing interests. (© 2024 The Author(s).)
Databáze:	MEDLINE
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