Elevated Cardiac Troponin I Level Associated to Cardiac Dysfunction in Burned Patients.

Autor:	Segura C; Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0644, USA., Golovko G; Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0644, USA., Obias I; Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0644, USA., Shah S; Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0644, USA., El Ayadi A; Department of Pharmacology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0644, USA., Wolf S; Department of Pharmacology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0644, USA., Song J; Department of Pharmacology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0644, USA.
Jazyk:	angličtina
Zdroj:	Journal of burn care & research : official publication of the American Burn Association [J Burn Care Res] 2024 Sep 06; Vol. 45 (5), pp. 1139-1147.
DOI:	10.1093/jbcr/irae086
Abstrakt:	Severely burned patients often develop cardiac dysfunction and heart failure. The purpose of this retrospective study is to evaluate the role of cardiac troponin I (cTI) and its association to patients with burns. Patients deidentified data were collected from a national database in May 2023. Adult patients with burns who had cTnI lab counted were enrolled in this study. Patients were grouped by the cTnI mean level within 72 h including patients with elevated cTnI levels at >0.3 ng/mL (n = 2188 patients) and patients with nonelevated cTnI level (<0.04 ng/mL) (n = 3200). The cohorts were further stratified by less than 20% TBSA mild burn population and >20% TBSA severe burn population to replicate the severity of burns. The 30-day incidences of acute myocardial infarction (MI), sepsis, and mortality were investigated after the cohorts were propensity-matching balanced. The odds ratios (ORs) with 95% CI for MI were (9.829/7.081-13.645), sepsis (1.527/1.269-1.959), and mortality (2.586/2.110-3.170), respectively (P < .05). The groups that were further stratified into mild burn and severe burn had the following results: The mild burn ORs and 95% CI for MI was (6.237/3.986-9.785), sepsis (1.603/1.132-2.270), and mortality was (2.298/1.629-3.242). The severe burn cohort had ORs and 95% CI for MI (3.145/1.469-6.732), sepsis (0.993/0.555-1.777), and mortality (2.934/1.924-4.475). In conclusion, the patients with earlier elevated cTnI levels had worse outcomes of MI and mortality in both severe and mild burns. (© The Author(s) 2024. Published by Oxford University Press on behalf of the American Burn Association. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
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