Sex Differences in Dystonia.

Autor: Kilic-Berkmen G; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA., Scorr LM; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA., McKay L; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.; Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA.; Department of Biomedical Engineering, Emory University and Georgia Tech, Atlanta, GA, USA., Thayani M; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA., Donsante Y; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, USA., Perlmutter JS; Department of Neurology, Radiology, Neuroscience, Physical Therapy and Occupational Therapy, Washington University School of Medicine, St Louis, MO, USA., Norris SA; Department of Neurology and Radiology, Washington University School of Medicine, St Louis, MO, USA., Wright L; Department of Neurology, Washington University School of Medicine, St Louis, MO, USA., Klein C; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany., Feuerstein JS; Department of Neurology, University of Colorado, Aurora, CO, USA., Mahajan A; Department of Neurological Sciences, Rush Parkinson's Disease and Movement Disorders Program, Chicago, IL, USA., Wagle-Shukla A; Fixel Institute for Neurological Disease, University of Florida Department of Neurology, University of Florida, Gainesville, FL, USA., Malaty I; Fixel Institute for Neurological Disease, University of Florida Department of Neurology, University of Florida, Gainesville, FL, USA., LeDoux MS; Department of Psychology, University of Memphis, Memphis, TN, USA.; Veracity Neuroscience LLC, Memphis, TN, USA., Pirio-Richardson S; Department of Neurology, University of New Mexico/New Mexico VA Healthcare System, Albuquerque, NM, USA., Pantelyat A; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Moukheiber E; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Frank S; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Ondo W; Movement Disorders Clinic, Methodist Neurological Institute, Houston, TX, USA., Saunders-Pullman R; Department of Neurology, Icahn School of Medicine at Mount Sinai, and Mount Sinai Beth Israel, New York, NY, USA., Lohmann K; Institute of Neurogenetics, University of Lübeck, Lübeck, Germany., Hess EJ; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, USA., Jinnah HA; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
Jazyk: angličtina
Zdroj: Movement disorders clinical practice [Mov Disord Clin Pract] 2024 Aug; Vol. 11 (8), pp. 973-982. Date of Electronic Publication: 2024 May 22.
DOI: 10.1002/mdc3.14059
Abstrakt: Background: Prior studies have indicated that female individuals outnumber male individuals for certain types of dystonia. Few studies have addressed factors impacting these sex differences or their potential biological mechanisms.
Objectives: To evaluate factors underlying sex differences in the dystonias and explore potential mechanisms for these differences.
Methods: Data from individuals with various types of dystonia were analyzed in relation to sex. Data came from two different sources. One source was the Dystonia Coalition database, which contains predominantly idiopathic adult-onset focal and segmental dystonias. The second source was the MDSGene database, which contains predominantly early-onset monogenic dystonias.
Results: The 3222 individuals from the Dystonia Coalition included 71% female participants and 29% male participants for an overall female-to-male ratio (F:M) of 2.4. This ratio varied according to body region affected and whether dystonia was task-specific. The female predominance was age-dependent. Sex did not have a significant impact on co-existing tremor, geste antagoniste, depression or anxiety. In the 1377 individuals from the MDSGene database, female participants outnumbered male participants for some genes (GNAL, GCH1, and ANO3) but not for other genes (THAP1, TH, and TOR1A).
Conclusions: These results are in keeping with prior studies that have indicated female individuals outnumber male individuals for both adult-onset idiopathic and early onset monogenic dystonias. These results extend prior observations by revealing that sex ratios depend on the type of dystonia, age, and underlying genetics.
(© 2024 International Parkinson and Movement Disorder Society.)
Databáze: MEDLINE
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