Resting state functional brain connectivity in child and adolescent psychiatry: where are we now?

Autor: Uddin LQ; Department of Psychiatry and Biobehavioral Science, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA, USA. lucina@ucla.edu.; Department of Psychology, University of California Los Angeles, Los Angeles, CA, USA. lucina@ucla.edu., Castellanos FX; Department of Child and Adolescent Psychiatry, New York University Grossman School of Medicine, New York, NY, USA.; Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA., Menon V; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
Jazyk: angličtina
Zdroj: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2024 Nov; Vol. 50 (1), pp. 196-200. Date of Electronic Publication: 2024 May 22.
DOI: 10.1038/s41386-024-01888-1
Abstrakt: Approaching the 30th anniversary of the discovery of resting state functional magnetic resonance imaging (rsfMRI) functional connectivity, we reflect on the impact of this neuroimaging breakthrough on the field of child and adolescent psychiatry. The study of intrinsic functional brain architecture that rsfMRI affords across a wide range of ages and abilities has yielded numerous key insights. For example, we now know that many neurodevelopmental conditions are associated with more widespread circuit alterations across multiple large-scale brain networks than previously suspected. The emergence of population neuroscience and effective data-sharing initiatives have made large rsfMRI datasets publicly available, providing sufficient power to begin to identify brain-based subtypes within heterogeneous clinical conditions. Nevertheless, several methodological and theoretical challenges must still be addressed to fulfill the promises of personalized child and adolescent psychiatry. In particular, incomplete understanding of the physiological mechanisms driving developmental changes in intrinsic functional connectivity remains an obstacle to further progress. Future directions include cross-species and multimodal neuroimaging investigations to illuminate such mechanisms. Data collection and harmonization efforts that span multiple countries and diverse cohorts are urgently needed. Finally, incorporating naturalistic fMRI paradigms such as movie watching should be a priority for future research efforts.
(© 2024. The Author(s).)
Databáze: MEDLINE
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