Optic disc drusen: Dystrophic calcification, a potential target for treatment.

Autor: Bentin JM; Department of Ophthalmology, Rigshospitalet, Glostrup, Denmark.; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark., Heegaard S; Department of Ophthalmology, Rigshospitalet, Glostrup, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Jørgensen NR; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Translational Research Centre, Rigshospitalet, Copenhagen, Denmark., Grahnemo L; Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Hamann S; Department of Ophthalmology, Rigshospitalet, Glostrup, Denmark. steffen.ellitsgaard.hamann@regionh.dk.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. steffen.ellitsgaard.hamann@regionh.dk.
Jazyk: angličtina
Zdroj: Eye (London, England) [Eye (Lond)] 2024 Aug; Vol. 38 (12), pp. 2359-2364. Date of Electronic Publication: 2024 May 22.
DOI: 10.1038/s41433-024-03138-6
Abstrakt: Optic disc drusen (ODD) are calcified, acellular bodies, seen in the optic nerve head of up to 2% of the population. Although seldomly affecting visual acuity, visual field defects are common, and severe, ischemic complications causing irreversible vision loss are known to occur. Different treatment strategies for ODD have been explored, but so far without success. This review focuses on the unique, calcified property of ODD, describing what we know about ODD pathogenesis and previously tried treatment strategies. In this context, we discuss current knowledge about calcium and pathological calcifications, including intracranial and ocular calcifications. We also explore some of the obstacles that must be addressed to develop a therapy centred on the concept of calcification, should calcification be identified as a pathogenic factor contributing to vision loss.
(© 2024. The Author(s), under exclusive licence to The Royal College of Ophthalmologists.)
Databáze: MEDLINE
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