Post-COVID conditions following COVID-19 vaccination: a retrospective matched cohort study of patients with SARS-CoV-2 infection.

Autor: Malden DE; Kaiser Permanente Southern California, Department of Research & Evaluation, Pasadena, USA. Debbie.E.Malden@kp.org., Liu IA; Kaiser Permanente Southern California, Department of Research & Evaluation, Pasadena, USA., Qian L; Kaiser Permanente Southern California, Department of Research & Evaluation, Pasadena, USA., Sy LS; Kaiser Permanente Southern California, Department of Research & Evaluation, Pasadena, USA., Lewin BJ; Kaiser Permanente Southern California, Department of Research & Evaluation, Pasadena, USA.; Kaiser Permanente Bernard J. Tyson School of Medicine, Department of Clinical Science, Pasadena, USA., Asamura DT; Kaiser Permanente Southern California, Department of Research & Evaluation, Pasadena, USA., Ryan DS; Kaiser Permanente Southern California, Department of Research & Evaluation, Pasadena, USA., Bezi C; Kaiser Permanente Southern California, Department of Research & Evaluation, Pasadena, USA., Williams JTB; Denver Health, Ambulatory Care Services & Center for Health Systems Research, Denver, USA., Kaiser R; HealthPartners Institute, Bloomington, USA., Daley MF; Kaiser Permanente Colorado, Institute for Health Research, Aurora, USA., Nelson JC; Kaiser Permanente Washington Health Research Institute (KPWHRI), Seattle, USA., McClure DL; Marshfield Clinic Research Institute, Marshfield, USA., Zerbo O; Kaiser Permanente Northern California, Division of Research, Vaccine Study Center, Oakland, USA., Henninger ML; Kaiser Permanente Northwest, Center for Health Research, Portland, USA., Fuller CC; Harvard Pilgrim Health Care Institute, Boston, USA., Weintraub ES; Centers for Disease Control and Prevention, Immunization Safety Office, Atlanta, GA, USA., Saydah S; Centers for Disease Control and Prevention, Immunization Safety Office, Atlanta, GA, USA., Tartof SY; Kaiser Permanente Southern California, Department of Research & Evaluation, Pasadena, USA.; Kaiser Permanente Bernard J. Tyson School of Medicine, Department of Health Systems Science, Pasadena, USA.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 May 22; Vol. 15 (1), pp. 4101. Date of Electronic Publication: 2024 May 22.
DOI: 10.1038/s41467-024-48022-9
Abstrakt: COVID-19 vaccinations protect against severe illness and death, but associations with post-COVID conditions (PCC) are less clear. We aimed to evaluate the association between prior COVID-19 vaccination and new-onset PCC among individuals with SARS-CoV-2 infection across eight large healthcare systems in the United States. This retrospective matched cohort study used electronic health records (EHR) from patients with SARS-CoV-2 positive tests during March 2021-February 2022. Vaccinated and unvaccinated COVID-19 cases were matched on location, test date, severity of acute infection, age, and sex. Vaccination status was ascertained using EHR and integrated data on externally administered vaccines. Adjusted relative risks (RRs) were obtained from Poisson regression. PCC was defined as a new diagnosis in one of 13 PCC categories 30 days to 6 months following a positive SARS-CoV-2 test. The study included 161,531 vaccinated COVID-19 cases and 161,531 matched unvaccinated cases. Compared to unvaccinated cases, vaccinated cases had a similar or lower risk of all PCC categories except mental health disorders (RR: 1.06, 95% CI: 1.02-1.10). Vaccination was associated with ≥10% lower risk of sensory (RR: 0.90, 0.86-0.95), circulatory (RR: 0.88, 0.83-0.94), blood and hematologic (RR: 0.79, 0.71-0.89), skin and subcutaneous (RR: 0.69, 0.66-0.72), and non-specific COVID-19 related disorders (RR: 0.53, 0.51-0.56). In general, associations were stronger at younger ages but mostly persisted regardless of SARS-CoV-2 variant period, receipt of ≥3 vs. 1-2 vaccine doses, or time since vaccination. Pre-infection vaccination was associated with reduced risk of several PCC outcomes and hence may decrease the long-term consequences of COVID-19.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: