Inflammasome functional activities in B lymphocytes.

Autor: Hsu ML; Graduate Institute of Biomedical Sciences, China Medical University, No. 91, Xueshi Road, North District, 404, Taichung, Taiwan., Jhuang KF; Graduate Institute of Biomedical Sciences, China Medical University, No. 91, Xueshi Road, North District, 404, Taichung, Taiwan., Zouali M; Graduate Institute of Biomedical Sciences, China Medical University, No. 91, Xueshi Road, North District, 404, Taichung, Taiwan. moncef.zouali@wanadoo.fr.
Jazyk: angličtina
Zdroj: Immunologic research [Immunol Res] 2024 Aug; Vol. 72 (4), pp. 828-840. Date of Electronic Publication: 2024 May 23.
DOI: 10.1007/s12026-024-09490-9
Abstrakt: Studies in animal models and human subjects have shown that, in addition to their implication in innate immunity, inflammasomes also can play a role in adaptive immunity. However, the contribution of the nucleotide-binding oligomerization domain-, leucine-rich repeat-, and pyrin domain-containing protein 3 (NLRP3) inflammasome pathway to adaptive immunity remains incompletely explored. Here, we show that NLRP3 plays an important role in different facets of B cell functions, including proliferation, antibody production, and secretion of inflammatory and anti-inflammatory cytokines. When exposed to B cell receptor engagement, Toll-like receptor activation, stimulation in conditions that mimic T cell-dependent responses, or NLRP3 activation, B cells manifest disparate responses and produce different cytokine patterns critical for modulating innate and adaptive immunity, indicating that the cytokines produced serve a critical link between the early innate immune response and the delayed adaptive immunity. Importantly, genetic ablation of nlrp3 reduced the inflammasome-mediated functions of B cells. We propose that, in the absence of other cell types, the potential of B lymphocytes to respond to NLRP3 engagement enables them to initiate inflammatory cascades through recruitment of other cell subsets, such as macrophages and neutrophils. Since NLRP3 activation of B cells is not followed by pyroptosis, even in the presence of a basal caspase-1 activity, this pathway acts as a bridge that optimizes interactions between the innate and adoptive branches of the immune response.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE