Eosinophilia During Lenalidomide Therapy in Myelodysplastic Syndrome.

Autor: Sasaki K; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address: ksasaki1@mdanderson.org., Kantarjian H; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Montalban-Bravo G; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Hammond D; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Jabbour E; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Kanagal-Shamanna R; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Chien K; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas., Garcia-Manero G; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Jazyk: angličtina
Zdroj: Clinical lymphoma, myeloma & leukemia [Clin Lymphoma Myeloma Leuk] 2024 Sep; Vol. 24 (9), pp. 629-633. Date of Electronic Publication: 2024 Apr 18.
DOI: 10.1016/j.clml.2024.04.007
Abstrakt: Background: Lenalidomide is an immunomodulatory therapy used to treat multiple hematologic malignancies. The incidence of eosinophilia and hypereosinophilia during lenalidomide therapy, and the requirement for high-dose steroids are not well-defined PATIENTS AND METHODS: We retrospectively reviewed 44 patients with myelodysplastic syndromes who were treated with lenalidomide therapy from August 2006 and March 2023.
Results: Eosinophilia (0.5-1.5 × 10 9 /L) and hypereosinophilia (>1.5 × 10 9 /L) were observed in 6 patients (14%) and 4 patients (9%), respectively. The median duration of lenalidomide therapy was 6.5 months. Backward multivariate ordinary logistic regression identified higher absolute eosinophil count (OR, 4759.986; 95% CI, 11.223-2018772.073; P = .006) and longer duration of lenalidomide therapy (OR, 1.148; 95% CI, 1.012-1.302; P = .032) as independent prognostic factors for the incidence of eosinophilia and hypereosinophilia. There was a trend for a higher use of high-dose steroids with hypereosinophilia. The median time to develop the first occurrence hypereosinophilia was 0.5 months. Steroids were used in 40% of patients with eosinophilia or hypereosinophilia. All events resolved with discontinuation of lenalidomide and/or use of steroids. No long-tern lasting adverse effects were recorded.
Conclusion: Lenalidomide may induce or worsen existing eosinophilia which may lead to the need for steroids within a month of therapy.
Competing Interests: Disclosures All authors declared no conflicts of interest related to this work. Koji Sasaki reports personal fees from Otsuka and Pfizer, outside the submitted work. Guillermo Garcia-Manero reports Gilead Sciences: Research Funding; Genentech: Honoraria, Research Funding; BMS: Consultancy, Honoraria, Research Funding; Aprea: Honoraria; AbbVie: Honoraria, Research Funding; Astex: Consultancy, Honoraria, Research Funding; Acceleron Pharma: Consultancy; Curis: Honoraria, Research Funding; Novartis: Honoraria, Research Funding. Elias Jabbour reports research funding from AbbVie, Adaptive Biotechnologies, Amgen, Bristol‐Myers Squibb, Cyclacel LTD, Pfizer, and Takeda; and personal fees from AbbVie, Adaptive Biotechnologies, Amgen, Bristol‐Myers Squibb, Pfizer, and Takeda, all outside the submitted work. Rashmi Kanagal-Shamanna received consultancy from Amgen, and Novartis, and served as Speakers Bureau for Aptitude Health, and Physicians Education Resource. Guillermo Montalban Bravo reports research funding from IFM Therapeutics. Lucia Masarova served as advisory committees at MorphoSys US. Hagop Kantarjian reports research grants and honoraria from AbbVie, Amgen, Ascentage, BMS, Daiichi-Sankyo, Immunogen, Jazz, Novartis, Pfizer and Sanofi; honoraria from Actinium (Advisory Board), Adaptive Biotechnologies, Aptitude Health, BioAscend, Delta Fly, Janssen Global, Oxford Biomedical and Takeda Oncology. WW reports Wierda:Gilead Sciences: Research Funding; Loxo Oncology, Inc./Lilly: Research Funding; Miragen: Research Funding; Bristol Meyers Squibb (Juno and Celgene): Research Funding; Kite, a Gilead Company: Research Funding; AstraZeneca/Acerta Pharma. Inc.: Research Funding; AbbVie: Research Funding; Pharmacyclics LLC: Research Funding; Sunesis: Research Funding; Xencor: Research Funding; Cyclacel: Research Funding; Genzyme: Consultancy; Genentech: Research Funding; Juno: Research Funding; Karyopharm: Research Funding; Sanofi: Consultancy; Oncternal Therapeutics, Inc.: Research Funding; Janssen: Research Funding; GSK/Novartis: Research Funding.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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