Persistent inflammation and nutritional status in Duchenne muscular dystrophy.

Autor: de Souza Costa ÁD; Postgraduate Program in Nutrition, Federal University of Rio Grande do Norte, Natal, RN, Brazil. Electronic address: adilasouza@gmail.com., Vermeulen-Serpa KM; Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil. Electronic address: karinavermeulen@hotmail.com., Batista Marinho KM; Postgraduate Program in Nutrition, Federal University of Rio Grande do Norte, Natal, RN, Brazil. Electronic address: kiviamariamarinho@gmail.com., Carvalho Xavier de Medeiros CA; Postgraduate Program in Biological Sciences/ Postgraduate Program in Biotechnology RENORBIO, Department of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal, Brazil. Electronic address: caroline.xavier@ufrn.br., Antunes de Araújo A; Postgraduate Program Public Health/ Postgraduate Program in Pharmaceutical Sciences, Department of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal, Brazil. Electronic address: aurigena.araujo@ufrn.br., Teixeira Dourado-Junior ME; Department of Internal Medicine, Federal University of Rio Grande do Norte, Natal, RN, Brazil. Electronic address: medourado03@gmail.com., Brandão-Neto J; Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil. Electronic address: brandao-neto@live.com., Lima Maciel BL; Postgraduate Program in Nutrition, Federal University of Rio Grande do Norte, Natal, RN, Brazil; Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil; Department of Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte Natal, Brazil. Electronic address: bruna.maciel@ufrn.br., Helena de Lima Vale S; Postgraduate Program in Nutrition, Federal University of Rio Grande do Norte, Natal, RN, Brazil; Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil; Department of Nutrition, Center for Health Sciences, Federal University of Rio Grande do Norte Natal, Brazil. Electronic address: sancha.vale@ufrn.br.
Jazyk: angličtina
Zdroj: Clinical nutrition ESPEN [Clin Nutr ESPEN] 2024 Jun; Vol. 61, pp. 393-398. Date of Electronic Publication: 2024 Apr 20.
DOI: 10.1016/j.clnesp.2024.04.014
Abstrakt: Background & Aims: Duchenne muscular dystrophy (DMD) involves muscle fragility, sarcolemma instability, and chronic inflammation. This study aims to identify the inflammatory profile of DMD patients and evaluate associations between clinical and nutritional variables.
Methods: We performed a cross-sectional study nested in a cohort to obtain sociodemographics, illness time, use of medications, and supplement data through interviews and the patient's medical records. Then, we assessed the relationships between illness time, cytokine levels, and nutritional status.
Results: Forty-four male participants, aged 4.3-24.2 years, were evaluated. Concerning nutritional status, 18 participants were eutrophic. The fat mass increased and the lean mass decreased from the beginning of the first signs of DMD. Cytokines levels in DMD patients, even under corticosteroids therapy, are higher than values described in the literature on healthy subjects. The regression models demonstrated that illness time and BMI/A z-scores are associated with higher values of interleukin-6.
Conclusions: A persistent inflammatory profile was observed in the patients evaluated. The data suggest that maintaining adequate nutritional status and body composition is important for determining the inflammation presented by individuals with DMD.
Competing Interests: Declaration of competing interest The authors declare no conflicts of interest.
(Copyright © 2024 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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