Diabetes and vitamin D: The effect of insulin sensitivity and gut microbial health.
| Autor: | Daley DK; Department of Biology, Mount Saint Vincent University, Halifax, NS, Canada; The College of Health Sciences, University of Technology, Kingston, Jamaica., Myrie SB; Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada; Richardson Centre for Food Technology and Research, University of Manitoba, Winnipeg, MB, Canada. Electronic address: Semone.Myrie@umanitoba.ca. |
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| Jazyk: | angličtina |
| Zdroj: | Advances in food and nutrition research [Adv Food Nutr Res] 2024; Vol. 109, pp. 160-184. Date of Electronic Publication: 2024 Apr 20. |
| DOI: | 10.1016/bs.afnr.2024.04.001 |
| Abstrakt: | Current global estimation suggests that about 10% of adults worldwide have diabetes, thus, various strategies are needed to address the issue, including dietary factors such as vitamin D. Various studies have suggested an inverse associations between vitamin D and the risks and pathogenesis of all forms of diabetes (type 1, type 2 and gestational diabetes). The underlying mechanism is not fully understood; however, the expression of vitamin D receptors in pancreatic beta cells suggests an important physiological role for vitamin D in beta cell function. Vitamin D deficiency may impair blood glucose control and decrease insulin sensitivity by reducing insulin secretion from beta cells. Many studies suggest that vitamin D intervention may be beneficial; however, there is inconclusive evidence of the effectiveness of vitamin D supplementation on reducing the risks or managing the pathogenesis of all forms of diabetes. Part of the pathogenesis of vitamin D for reducing diabetes is thought to be related to its impact on gut microbiota profile, via the suggested prebiotic properties of vitamin D. (Copyright © 2024. Published by Elsevier Inc.) |
| Databáze: | MEDLINE |
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