Study of activation cross sections of double neutron capture reaction on 193 Ir for the reactor production route of radiotherapeutic 195m Pt.

Autor: Madumarov AS; Flerov Laboratory of Nuclear Reactions, Joint Institute for Nuclear Research, Joliot-Curie 6, 141980 Dubna, Russia. Electronic address: al.madumarov@jinr.ru., Aksenov NV; Flerov Laboratory of Nuclear Reactions, Joint Institute for Nuclear Research, Joliot-Curie 6, 141980 Dubna, Russia. Electronic address: nikolay.aksenov@jinr.ru., Bozhikov GA; Flerov Laboratory of Nuclear Reactions, Joint Institute for Nuclear Research, Joliot-Curie 6, 141980 Dubna, Russia. Electronic address: bozhikov@jinr.ru., Astakhov AA; Flerov Laboratory of Nuclear Reactions, Joint Institute for Nuclear Research, Joliot-Curie 6, 141980 Dubna, Russia. Electronic address: astakhov@jinr.ru., Albin YV; Flerov Laboratory of Nuclear Reactions, Joint Institute for Nuclear Research, Joliot-Curie 6, 141980 Dubna, Russia. Electronic address: albin@jinr.ru., Bulavin MV; Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Joliot-Curie 6, 141980 Dubna, Russia., Shabalin EP; Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Joliot-Curie 6, 141980 Dubna, Russia. Electronic address: shab36@nf.jinr.ru., Dmitriev SN; Flerov Laboratory of Nuclear Reactions, Joint Institute for Nuclear Research, Joliot-Curie 6, 141980 Dubna, Russia. Electronic address: dmitriev@jinr.ru.
Jazyk: angličtina
Zdroj: Nuclear medicine and biology [Nucl Med Biol] 2024 Jul-Aug; Vol. 134-135, pp. 108928. Date of Electronic Publication: 2024 May 18.
DOI: 10.1016/j.nucmedbio.2024.108928
Abstrakt: The radiotherapeutic 195m Pt is among the most effective Auger electron emitters of the currently studied radionuclides that have a potential theranostic application in nuclear medicine. Production of 195m Pt through double neuron capture of enriched 193 Ir followed by β - -decay to the radioisotope of interest carried out at the research reactor IBR-2 is described. Because of the high radiation background, radiochemical purification procedure of 195m Pt from bulk of iridium was needed to be developed and is detailed here as well. For the first time, cross section and resonance integral for the reaction 194 Ir(n,γ) 195m Ir were determined. Resonance neutrons contribution was established to exceed that of thermal neutrons, and resonance integral for the reaction 194 Ir(n,γ) 195m Ir is calculated to be 2900 b. Specific activity of 195m Pt was estimated to reach a value of 38.7 GBq/(g Pt) at IBR-2 by the end of bombardment (EOB).
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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