Managing recurrent parvovirus B19-associated anemia after a pediatric kidney transplant.

Autor: Sabanci M; İstinye University School of Medicine, Istanbul, Turkey., Taşdemir M; Division of Pediatric Nephrology, Department of Pediatrics, İstinye University School of Medicine, Azerbaycan Caddesi, No: 4/A, Sarıyer, Istanbul, Türkiye. mehmet.tasdemir@istinye.edu.tr., Öksüz B; Molecular Infection Laboratory, Genetic Diseases Diagnosis Center, İstinye University, Istanbul, Turkey., Altuner Torun Y; Division of Pediatric Hematology, Department of Pediatrics, İstinye University School of Medicine, Istanbul, Turkey., Sütçü M; Division of Pediatric Infectious Disease, Department of Pediatrics, İstinye University School of Medicine, Istanbul, Turkey., Özkaya O; Division of Pediatric Nephrology, Department of Pediatrics, İstinye University School of Medicine, Azerbaycan Caddesi, No: 4/A, Sarıyer, Istanbul, Türkiye.
Jazyk: angličtina
Zdroj: Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2024 Oct; Vol. 39 (10), pp. 2923-2925. Date of Electronic Publication: 2024 May 22.
DOI: 10.1007/s00467-024-06378-6
Abstrakt: A 13-year-old girl who had a kidney transplant four weeks prior presented with a 10-day history of fatigue, paleness, and headache. On physical examination, tachycardia and paleness were noted. Laboratory testing was notable for severe anemia and mild leukopenia and thrombocytopenia. Polymerase chain reaction (PCR) test for Epstein-Barr virus (EBV) and cytomegalovirus (CMV) were negative and for parvovirus B19 (PVB19) was positive. Despite lower immunosuppression and administration of intravenous immunoglobulin (IVIG) it persisted for 15 months, and frequent red blood cell transfusions were needed. PVB19 is a less common but significant complication. The patient's clinical course demonstrates the importance of this complication and the challenges in its management. A notable void exists in the literature regarding standardized treatment protocols for PVB19-induced recurrent anemia after kidney transplant. This case indicates the need for further research and consensus to guide effective clinical interventions in similar cases.
(© 2024. The Author(s).)
Databáze: MEDLINE
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