No genetic causal association between iron status and pulmonary artery hypertension: Insights from a two-sample Mendelian randomization.

Autor: Liu PC; Department of Rheumatology, The First Affiliated Hospital, Jiangxi Medical College Nanchang University Nanchang China., Lv MN; The First Clinical Medical College of Nanchang University Nanchang China., Rong YY; Department of Hematology, The First Affiliated Hospital, Jiangxi Medical College Nanchang University Nanchang China., Yu SJ; Department of Rheumatology, The First Affiliated Hospital, Jiangxi Medical College Nanchang University Nanchang China., Wu R; Department of Rheumatology, The First Affiliated Hospital, Jiangxi Medical College Nanchang University Nanchang China.
Jazyk: angličtina
Zdroj: Pulmonary circulation [Pulm Circ] 2024 Apr 17; Vol. 14 (2), pp. e12370. Date of Electronic Publication: 2024 Apr 17 (Print Publication: 2024).
DOI: 10.1002/pul2.12370
Abstrakt: To explore the genetic causal association between pulmonary artery hypertension (PAH) and iron status through Mendelian randomization (MR), we conducted MR analysis using publicly available genome-wide association study (GWAS) summary data. Five indicators related to iron status (serum iron, ferritin, total iron binding capacity (TIBC), soluble transferrin receptor (sTfR), and transferrin saturation) served as exposures, while PAH was the outcome. The genetic causal association between these iron status indicators and PAH was assessed using the inverse variance weighted (IVW) method. Cochran's Q statistic was employed to evaluate heterogeneity. We assessed pleiotropy using MR-Egger regression and MR-Presso test. Additionally, we validated our results using the Weighted median, Simple mode, and Weighted mode methods. Based on the IVW method, we found no causal association between iron status (serum iron, ferritin, TIBC, sTfR, and transferrin saturation) and PAH ( p β  > 0.05). The Weighted median, Simple mode, and Weighted mode methods showed no potential genetic causal association ( p β  > 0.05 in the three analyses). Additionally, no heterogeneity or horizontal pleiotropy was detected in any of the analyses. Our results show that there are no genetic causal association between iron status and PAH.
Competing Interests: The authors declare no conflict of interest.
(© 2024 The Authors. Pulmonary Circulation published by John Wiley & Sons Ltd on behalf of Pulmonary Vascular Research Institute.)
Databáze: MEDLINE
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