The Role of JAK-STAT-SOCS1 Axis in Tumorigenesis, Malignant Progression and Lymphatic Metastasis of Penile Cancer.

Autor:	Xu DM; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, P. R. China.; Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou 510060, P.R. China., Chen LX; Department of Urology, Xiangya Hospital, Central South University, Changsha 410008, P.R. China., Zhuang XY; Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, P. R. China., Han H; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, P. R. China.; Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou 510060, P.R. China., Mo M; Department of Urology, Xiangya Hospital, Central South University, Changsha 410008, P.R. China.
Jazyk:	angličtina
Zdroj:	International journal of medical sciences [Int J Med Sci] 2024 Apr 29; Vol. 21 (6), pp. 1176-1186. Date of Electronic Publication: 2024 Apr 29 (Print Publication: 2024).
DOI:	10.7150/ijms.95490
Abstrakt:	Background: To uncover the potential significance of JAK-STAT-SOCS1 axis in penile cancer, our study was the pioneer in exploring the altered expression processes of JAK-STAT-SOCS1 axis in tumorigenesis, malignant progression and lymphatic metastasis of penile cancer. Methods: In current study, the comprehensive analysis of JAK-STAT-SOCS1 axis in penile cancer was analyzed via multiple analysis approaches based on GSE196978 data, single-cell data (6 cancer samples) and bulk RNA data (7 cancer samples and 7 metastasis lymph nodes). Results: Our study observed an altered molecular expression of JAK-STAT-SOCS1 axis during three different stages of penile cancer, from tumorigenesis to malignant progression to lymphatic metastasis. STAT4 was an important dominant molecule in penile cancer, which mediated the immunosuppressive tumor microenvironment by driving the apoptosis of cytotoxic T cell and was also a valuable biomarker of immune checkpoint inhibitor treatment response. Conclusions: Our findings revealed that the complexity of JAK-STAT-SOCS1 axis and the predominant role of STAT4 in penile cancer, which can mediate tumorigenesis, malignant progression, and lymphatic metastasis. This insight provided valuable information for developing precise treatment strategies for patients with penile cancer. Competing Interests: Competing Interests: The authors have declared that no competing interest exists. (© The author(s).)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu