Changes in left atrial function following two regimens of combined exercise training in patients with ischemic cardiomyopathy: a pilot study.

Autor:	Caminiti G; Department of Human Science and Promotion of Quality of Life, San Raffaele Open University, Rome, Italy.; Cardiology Rehabilitation Unit, IRCCS San Raffaele, Rome, Italy., Volterrani M; Department of Human Science and Promotion of Quality of Life, San Raffaele Open University, Rome, Italy.; Cardiology Rehabilitation Unit, IRCCS San Raffaele, Rome, Italy., Iellamo F; Division of Cardiology and Sports Medicine, Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy., Marazzi G; Cardiology Rehabilitation Unit, IRCCS San Raffaele, Rome, Italy., Manzi V; Department of Wellbeing, Nutrition and Sport, Pegaso Open University, Naples, Italy., D'Antoni V; Cardiology Rehabilitation Unit, IRCCS San Raffaele, Rome, Italy., Vadalà S; Cardiology Rehabilitation Unit, IRCCS San Raffaele, Rome, Italy., Di Biasio D; Cardiology Rehabilitation Unit, IRCCS San Raffaele, Rome, Italy., Catena M; Cardiology Rehabilitation Unit, IRCCS San Raffaele, Rome, Italy., Morsella V; Cardiology Rehabilitation Unit, IRCCS San Raffaele, Rome, Italy., Perrone MA; Division of Cardiology and Sports Medicine, Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.
Jazyk:	angličtina
Zdroj:	Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2024 May 07; Vol. 11, pp. 1377958. Date of Electronic Publication: 2024 May 07 (Print Publication: 2024).
DOI:	10.3389/fcvm.2024.1377958
Abstrakt:	Purpose: Left atrial dysfunction has shown to play a prognostic role in patients with ischemic cardiomyopathy (ICM) and is becoming a therapeutic target for pharmacological and non-pharmacological interventions. The effects of exercise training on the atrial function in patients with ICM have been poorly investigated. In the present study, we assessed the effects of a 12-week combined training (CT) program on the left atrial function in patients with ICM. Methods: We enlisted a total of 45 clinically stable patients and randomly assigned them to one of the following three groups: 15 to a supervised CT with low-frequency sessions (twice per week) (CTLF); 15 to a supervised CT with high-frequency sessions (thrice per week) (CTHF); and 15 to a control group following contemporary preventive exercise guidelines at home. At baseline and 12 weeks, all patients underwent a symptom-limited exercise test and echocardiography. The training included aerobic continuous exercise and resistance exercise. The analysis of variance (ANOVA) was used to compare within- and inter-group changes. Results: At 12 weeks, the CTLF and CTHF groups showed a similar increase in the duration of the ergometric test compared with the control (ANOVA p  < 0.001). The peak atrial longitudinal strain significantly increased in the CTHF group, while it was unchanged in the CTLF and control groups (ANOVA p  = 0.003). The peak atrial contraction strain presented a significant improvement in the CTHF group compared with the CTLF and control groups. The left ventricular global longitudinal strain significantly increased in both the CTHF and the CTLF groups compared with the control group (ANOVA p  = 0.017). The systolic blood pressure decreased in the CTHF and CTLF groups, while it was unchanged in the control group. There were no side effects causing the discontinuation of the training. Conclusions: We demonstrated that a CT program effectively improved atrial function in patients with ICM in a dose-effect manner. This result can help with programming exercise training in this population. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors declared that they were an editorial board member of Frontiers at the time of submission. This had no impact on the peer-review process and the final decision. (© 2024 Caminiti, Volterrani, Iellamo, Marazzi, Manzi, D'Antoni, Vadalà, Di Biasio, Catena, Morsella and Perrone.)
Databáze:	MEDLINE
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