Photoplethysmography and intracardiac pressures: early insights from a pilot study.

Autor:	Scholte NTB; Department of Cardiology, Cardiovascular Institute, Erasmus Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands., van Ravensberg AE; Department of Cardiology, Cardiovascular Institute, Erasmus Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands., Edgar R; Department of Cardiology, Radboud University Medical Center, Nijmegen, the Netherlands., van den Enden AJM; Department of Cardiology, Cardiovascular Institute, Erasmus Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands., van Mieghem NMDA; Department of Cardiology, Cardiovascular Institute, Erasmus Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands., Brugts JJ; Department of Cardiology, Cardiovascular Institute, Erasmus Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands., Bonnes JL; Department of Cardiology, Radboud University Medical Center, Nijmegen, the Netherlands., Bruining N; Department of Cardiology, Cardiovascular Institute, Erasmus Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands., van der Boon RMA; Department of Cardiology, Cardiovascular Institute, Erasmus Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands.
Jazyk:	angličtina
Zdroj:	European heart journal. Digital health [Eur Heart J Digit Health] 2024 Mar 07; Vol. 5 (3), pp. 379-383. Date of Electronic Publication: 2024 Mar 07 (Print Publication: 2024).
DOI:	10.1093/ehjdh/ztae020
Abstrakt:	Aims: Invasive haemodynamic monitoring of heart failure (HF) is used to detect deterioration in an early phase thereby preventing hospitalizations. However, this invasive approach is costly and presently lacks widespread accessibility. Hence, there is a pressing need to identify an alternative non-invasive method that is reliable and more readily available. In this pilot study, we investigated the relation between wrist-derived photoplethysmography (PPG) signals and the invasively measured pulmonary capillary wedge pressure (PCWP). Methods and Results: Fourteen patients with aortic valve stenosis who underwent transcatheter aortic valve replacement with concomitant right heart catheterization and PPG measurements were included. Six unique features of the PPG signals [heart rate, heart rate variability, systolic amplitude (SA), diastolic amplitude, crest time (CT), and large artery stiffness index (LASI)] were extracted. These features were used to estimate the continuous PCWP values and the categorized PCWP (low < 12 mmHg vs. high ≥ 12 mmHg). All PPG features resulted in regression models that showed low correlations with the invasively measured PCWP. Classification models resulted in higher performances: the model based on the SA and the model based on the LASI both resulted in an area under the curve (AUC) of 0.86 and the model based on the CT resulted in an AUC of 0.72. Conclusion: These results demonstrate the capability to non-invasively classify patients into clinically meaningful categories of PCWP using PPG signals from a wrist-worn wearable device. To enhance and fully explore its potential, the relationship between PPG and PCWP should be further investigated in a larger cohort of HF patients. Competing Interests: Conflict of interest: N.T.B.S. none; A.E.v.R. none; R.E. none; A.J.M.v.d.E. none. N.M.D.A.v.M. received institutional research grant support outside the scope of the submitted work from Abbott, Teleflex, Astra Zenica, PulseCath BV, Pie Medical, Boston Scientific, Daiichi-Sankyo, Edward Lifesciences, Medtronic, Biotronik, and CSI; J.J.B. received independent research grant from Abbott to the institute for ISS and has had speaker engagement or advisory boards in the past 5 years with Astra Zeneca, Abbott, Boehringer-Ingelheim, Bayer, Daiichi Sankyo, Novartis, and Vifor; J.L.B. none; N.B. none. R.M.A.v.d.B. received an independent research grant to the institute from Abbott and has had speaker engagement or advisory boards in the past 5 years with Abbott, Boehringer Ingelheim, and Bayer. (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)
Databáze:	MEDLINE
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