Mild and efficient synthesis and base-promoted rearrangement of novel isoxazolo[4,5- b ]pyridines.
| Autor: | Nikol'skiy VV; N.D. Zelinsky Institute of Organic Chemistry RAS, Leninsky prosp. 47, 119991 Moscow, Russia., Minyaev ME; N.D. Zelinsky Institute of Organic Chemistry RAS, Leninsky prosp. 47, 119991 Moscow, Russia., Bastrakov MA; N.D. Zelinsky Institute of Organic Chemistry RAS, Leninsky prosp. 47, 119991 Moscow, Russia., Starosotnikov AM; N.D. Zelinsky Institute of Organic Chemistry RAS, Leninsky prosp. 47, 119991 Moscow, Russia. |
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| Jazyk: | angličtina |
| Zdroj: | Beilstein journal of organic chemistry [Beilstein J Org Chem] 2024 May 14; Vol. 20, pp. 1069-1075. Date of Electronic Publication: 2024 May 14 (Print Publication: 2024). |
| DOI: | 10.3762/bjoc.20.94 |
| Abstrakt: | An efficient method for the synthesis of isoxazolo[4,5- b ]pyridines has been developed on the basis of readily available 2-chloro-3-nitropyridines via the intramolecular nucleophilic substitution of the nitro group as a key step. The previously unknown base-promoted Boulton-Katritzky rearrangement of isoxazolo[4,5- b ]pyridine-3-carbaldehyde arylhydrazones into 3-hydroxy-2-(2-aryl[1,2,3]triazol-4-yl)pyridines was observed. (Copyright © 2024, Nikol’skiy et al.) |
| Databáze: | MEDLINE |
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