Mucosal-associated invariant T cells modulate innate immune cells and inhibit colon cancer growth.

Autor: Cheng OJ; Division of Microbiology & Immunology, Department of Pathology, University of Utah, Salt Lake City, Utah, USA.; Division of Infectious Disease, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA., Lebish EJ; Division of Gastroenterology, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA., Jensen O; Division of Microbiology & Immunology, Department of Pathology, University of Utah, Salt Lake City, Utah, USA.; Division of Infectious Disease, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA., Jacenik D; Division of Gastroenterology, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.; Department of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland., Trivedi S; Division of Infectious Disease, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA., Cacioppo JG; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Aubé J; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Beswick EJ; Division of Gastroenterology, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.; Division of Digestive Diseases and Nutrition, Department of Internal Medicine, University of Kentucky, Lexington, Kentucky, USA., Leung DT; Division of Microbiology & Immunology, Department of Pathology, University of Utah, Salt Lake City, Utah, USA.; Division of Infectious Disease, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA.
Jazyk: angličtina
Zdroj: Scandinavian journal of immunology [Scand J Immunol] 2024 Sep; Vol. 100 (3), pp. e13391. Date of Electronic Publication: 2024 May 21.
DOI: 10.1111/sji.13391
Abstrakt: Mucosal-associated invariant T (MAIT) cells are innate-like T cells that can be activated by microbial antigens and cytokines and are abundant in mucosal tissues including the colon. MAIT cells have cytotoxic and pro-inflammatory functions and have potentials for use as adoptive cell therapy. However, studies into their anti-cancer activity, including their role in colon cancer, are limited. Using an animal model of colon cancer, we showed that peritumoral injection of in vivo-expanded MAIT cells into RAG1 -/- mice with MC38-derived tumours inhibits tumour growth compared to control. Multiplex cytokine analyses showed that tumours from the MAIT cell-treated group have higher expression of markers for eosinophil-activating cytokines, suggesting a potential association between eosinophil recruitment and tumour inhibition. In a human peripheral leukocyte co-culture model, we showed that leukocytes stimulated with MAIT ligand showed an increase in eotaxin-1 production and activation of eosinophils, associated with increased cancer cell killing. In conclusion, we showed that MAIT cells have a protective role in a murine colon cancer model, associated with modulation of the immune response to cancer, potentially involving eosinophil-associated mechanisms. Our results highlight the potential of MAIT cells for non-donor restricted colon cancer immunotherapy.
(© 2024 The Author(s). Scandinavian Journal of Immunology published by John Wiley & Sons Ltd on behalf of The Scandinavian Foundation for Immunology.)
Databáze: MEDLINE
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