Bedsore Healing Using Selenium-Enriched Lactobacillus brevis LSe: A Randomized, Double-Blind, Controlled Clinical Trial.

Autor: Ataollahi F; Extremophile and Productive Microorganisms Research Center, Kerman University of Medical Sciences, Kerman, Iran., Amirheidari B; Extremophile and Productive Microorganisms Research Center, Kerman University of Medical Sciences, Kerman, Iran. b_amirheidari@kmu.ac.ir.; Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, 76169-13555, Iran. b_amirheidari@kmu.ac.ir.; Department of Pharmaceutical; Biotechnology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran. b_amirheidari@kmu.ac.ir., Ahmadinejad M; Department of Anesthesiology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran., Khoshnam Z; Department of Anesthesiology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran., Shakibaie M; Pharmaceutical Sciences and Cosmetic Products Research Center, Kerman University of Medical Sciences, Kerman, Iran.; Department of Pharmaceutical; Biotechnology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran., Forootanfar H; Pharmaceutical Sciences and Cosmetic Products Research Center, Kerman University of Medical Sciences, Kerman, Iran.; Department of Pharmaceutical; Biotechnology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran., Nooshadokht M; Extremophile and Productive Microorganisms Research Center, Kerman University of Medical Sciences, Kerman, Iran., Shabani M; Kerman Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Science, Kerman, Iran., Ramezani Nejad M; Extremophile and Productive Microorganisms Research Center, Kerman University of Medical Sciences, Kerman, Iran., Khodabakhshi A; Department of Nutrition, Faculty of Public Health, Kerman University of Medical Sciences, Kerman, Iran., Amirheidari Z; Extremophile and Productive Microorganisms Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Jazyk: angličtina
Zdroj: Biological trace element research [Biol Trace Elem Res] 2024 May 21. Date of Electronic Publication: 2024 May 21.
DOI: 10.1007/s12011-024-04233-1
Abstrakt: Bedsores impose an important challenge to the healthcare system. Se-baring probiotics are considered effective agents in wound healing and inflammation reduction via several pathways. The present study focused on the administration of a Se-enriched probiotic, originally obtained from a traditional dairy product for bedsore healing. Daily doses of the probiotic were administered to 20 ICU patients for 14 days and the wound healing criteria were compared with those of the same group of ICU patients as control, both groups suffering from stages I and II bedsore (a randomized, double-blind, controlled clinical trial). The administered Se-enriched probiotic decreased the bedsore healing period significantly (on average by 2.4 days, P-value: 0.039), as well as bedsore size (on average by 7 mm 2 , nonsignificant) and bedsore grade (10%, nonsignificant) in the treatment group more efficiently than the control group. Some key laboratory parameters associated with inflammation were also improved in patients receiving the Se-supplemented probiotic. The limitations of this study include the low number of patients meeting inclusion criteria within the timeframe of the study, and the impossibility of following up patients after discharge from the ICU. In summary, this study revealed the effectiveness of the Se-enriched probiotic in bedsore improvement, suggesting consideration of the enriched probiotic as an auxiliary agent in bedsore management.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: