Stem cells, cell therapies, and bioengineering in lung biology and diseases 2023.

Autor: Hynds RE; Epithelial Cell Biology in ENT Research Group, Developmental Biology and Cancer Department, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Magin CM; Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.; Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States., Ikonomou L; Department of Oral Biology, University at Buffalo, State University of New York, Buffalo, New York, United States.; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University at Buffalo, State University of New York, Buffalo, New York, United States., Aschner Y; Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States., Beers MF; Pulmonary, Allergy, and Critical Care Division, Department of Medicine and PENN-CHOP Lung Biology Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States., Burgess JK; Department of Pathology and Medical Biology, University Medical Center Groningen, Groningen, The Netherlands., Heise RL; Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia, United States., Hume PS; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, Colorado, United States., Krasnodembskaya AD; Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom., Mei SHJ; Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada., Misharin AV; Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States., Park JA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, United States., Reynolds SD; Center for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States., Tschumperlin DJ; Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, United States., Tanneberger AE; Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States., Vaidyanathan S; Center for Gene Therapy, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States., Waters CM; Department of Physiology and Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, United States., Zettler PJ; Moritz College of Law, Drug Enforcement and Policy Center, The James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States., Weiss DJ; Department of Medicine, University of Vermont, Burlington, Vermont, United States., Ryan AL; Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States.
Jazyk: angličtina
Zdroj: American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2024 Sep 01; Vol. 327 (3), pp. L327-L340. Date of Electronic Publication: 2024 May 21.
DOI: 10.1152/ajplung.00052.2024
Abstrakt: Repair and regeneration of a diseased lung using stem cells or bioengineered tissues is an exciting therapeutic approach for a variety of lung diseases and critical illnesses. Over the past decade, increasing evidence from preclinical models suggests that mesenchymal stromal cells, which are not normally resident in the lung, can be used to modulate immune responses after injury, but there have been challenges in translating these promising findings to the clinic. In parallel, there has been a surge in bioengineering studies investigating the use of artificial and acellular lung matrices as scaffolds for three-dimensional lung or airway regeneration, with some recent attempts of transplantation in large animal models. The combination of these studies with those involving stem cells, induced pluripotent stem cell derivatives, and/or cell therapies is a promising and rapidly developing research area. These studies have been further paralleled by significant increases in our understanding of the molecular and cellular events by which endogenous lung stem and/or progenitor cells arise during lung development and participate in normal and pathological remodeling after lung injury. For the 2023 Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases Conference, scientific symposia were chosen to reflect the most cutting-edge advances in these fields. Sessions focused on the integration of "omics" technologies with function, the influence of immune cells on regeneration, and the role of the extracellular matrix in regeneration. The necessity for basic science studies to enhance fundamental understanding of lung regeneration and to design innovative translational studies was reinforced throughout the conference.
Databáze: MEDLINE