Update on chiral recognition mechanisms in separation science.

Autor: Scriba GKE; Department of Pharmaceutical/Medicinal Chemistry, Friedrich Schiller University, Jena, Germany.
Jazyk: angličtina
Zdroj: Journal of separation science [J Sep Sci] 2024 May; Vol. 47 (9-10), pp. e2400148.
DOI: 10.1002/jssc.202400148
Abstrakt: The stereospecific analysis of chiral molecules is an important issue in many scientific fields. In separation sciences, this is achieved via the formation of transient diastereomeric complexes between a chiral selector and the selectand enantiomers driven by molecular interactions including electrostatic, ion-dipole, dipole-dipole, van der Waals or π-π interactions as well as hydrogen or halogen bonds depending on the nature of selector and selectand. Nuclear magnetic resonance spectroscopy and molecular modeling methods are currently the most frequently applied techniques to understand the selector-selectand interactions at a molecular level and to draw conclusions on the chiral separation mechanism. The present short review summarizes some of the recent achievements for the understanding of the chiral recognition of the most important chiral selectors combining separation techniques with molecular modeling and/or spectroscopic techniques dating between 2020 and early 2024. The selectors include polysaccharide derivatives, cyclodextrins, macrocyclic glycopeptides, proteins, donor-acceptor type selectors, ion-exchangers, crown ethers, and molecular micelles. The application of chiral ionic liquids and chiral deep eutectic solvents, as well as further selectors, are also briefly addressed. A compilation of all published literature on chiral selectors has not been attempted.
(© 2024 The Authors. Journal of Separation Science published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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