Unveiling the intricacies of BPA and BPS: comprehensive insights into its toxic effects using a cutting-edge microphysiological system.

Autor: Ganzerla MD; Nacional Bioscience Laboratory, CNPEM, Campinas, Brazil., Indolfo NC; Natura Co, São Paulo, Brazil., Oliveira LCM; Nacional Bioscience Laboratory, CNPEM, Campinas, Brazil., Doratioto TR; Natura Co, São Paulo, Brazil., Avelino TM; Nacional Bioscience Laboratory, CNPEM, Campinas, Brazil., de Azevedo RJ; Nacional Bioscience Laboratory, CNPEM, Campinas, Brazil., Tofani LB; Nacional Bioscience Laboratory, CNPEM, Campinas, Brazil., Terra MF; Nacional Bioscience Laboratory, CNPEM, Campinas, Brazil., Elias GB; Nacional Bioscience Laboratory, CNPEM, Campinas, Brazil., de Sousa IL; Nacional Bioscience Laboratory, CNPEM, Campinas, Brazil., Alborguetti MR; Nacional Bioscience Laboratory, CNPEM, Campinas, Brazil., Rocco SA; Nacional Bioscience Laboratory, CNPEM, Campinas, Brazil., Arroteia KF; Natura Co, São Paulo, Brazil., Figueira ACM; Nacional Bioscience Laboratory, CNPEM, Campinas, Brazil. Electronic address: ana.figueira@lnbio.cnpem.br.
Jazyk: angličtina
Zdroj: Toxicology in vitro : an international journal published in association with BIBRA [Toxicol In Vitro] 2024 Jun; Vol. 98, pp. 105849. Date of Electronic Publication: 2024 May 19.
DOI: 10.1016/j.tiv.2024.105849
Abstrakt: Concerns over Bisphenol A (BPA) and its substitute, Bisphenol S (BPS), have led to innovative exploration due to potential adverse health effects. BPS, replacing BPA in some regions to avoid toxic impacts, remains insufficiently studied. Besides this, the organ-on-a-chip technology emerges as a transformative solution in drug discovery and chemiclas toxicity testing, minimizing costs and aligning with ethical standards by reducing reliance on animal models, by integrating diverse tissues and dynamic cell environments enhances precision in predicting organ function. Here, we employ a 3-organ-on-a-chip microfluidic device with skin, intestine, and liver cultures to assess the effects of BPA and BPS via topical and oral administration. Our evaluation focused on gene markers associated with carcinogenicity, systemic toxicity, and endocrine disruption. BPA exhibited expected absorption profiles, causing liver injury and genetic modulation in related pathways. BPS, a safer alternative, induced adverse effects on gene expression, particularly in topical absorption, with distinct absorption patterns. Our findings underscore the urgency of addressing BPA and BPS toxicity concerns, highlighting the crucial role of organ-on-a-chip technology in understanding associated health risks. The study promotes the organ-on-a-chip methodology as a valuable tool for safe drug development and disease treatments, offering a novel liver toxicity screening alternative to traditional animal tests. This contributes to advancing comprehension of the biological effects of these compounds, fostering improved safety assessments in human health.
Competing Interests: Declaration of competing interest Ana Carolina M Figueira reports financial support was provided by Natura and Co. Ana Carolina M Figueira reports a relationship with Natura and Co that includes: funding grants. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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