Toward a multi-layer micro-structured detector for high-energy electron radiotherapy.

Autor: Brivio D; Brigham and Women's Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA., Liles A; Brigham and Women's Hospital, Boston, Massachusetts, USA.; Department of Physics, University of Massachusetts Lowell, Lowell, Massachusetts, USA., Gagne M; Department of Physics, University of Massachusetts Lowell, Lowell, Massachusetts, USA.; RayWatch Inc., Hopkinton, Hopkinton, Massachusetts, USA., Sajo E; Department of Physics, University of Massachusetts Lowell, Lowell, Massachusetts, USA., Zygmanski P; Brigham and Women's Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.
Jazyk: angličtina
Zdroj: Medical physics [Med Phys] 2024 Sep; Vol. 51 (9), pp. 6412-6422. Date of Electronic Publication: 2024 May 21.
DOI: 10.1002/mp.17134
Abstrakt: Background: The use of electron beams has been rekindled by the advent of ultra-high-dose rate radiotherapy (FLASH) and very high energy electrons (VHEE). The need for development of novel technology for beam monitoring and dosimetry of such beams is of paramount importance prior to their clinical translation.
Purpose: In this work we explore the potential of a multi-layer nanoporous aerogel High-Energy-Current (HEC) detector as a dosimeter for electron beam. The detector does not suffer from radiation damage or signal saturation, making it suitable for very-high-dose-rate applications. Standard dose rates and energies are used to establish reference for FLASH and VHEE. We explore detector response to electron energy and residual range both experimentally and computationally.
Methods: Multilayer HEC detectors were constructed using 1×-10× basic modules of Aluminum(Al)_aerogel(A)_Tantalum(Ta) with 10-70 µm layer thicknesses. Signals are collected from all electrodes (3-21, depending on module multiplicity) with zero external voltage bias. Measurements are acquired as a function of depth(z) in water equivalent plastic using Varian TrueBeam for energies E = 6,9,12,15 MeV (SAD = 105 cm, 6 × 6 cone, 1000 MU/min). Computational simulations of identical detector geometries are performed using the 1D deterministic code CEPXS/ONEDANT. Additionally, percent-depth-doses PDD(z), measured with diode in water, are used to explore the response of HEC for various energies and residual ranges.
Results: The current measured from Ta electrodes resembles the shape of deposited charges in water and it is proportional to the derivative of the clinical PDD corrected for contribution from photon contamination. The signal is positive on the surface, and it decreases with depth reaching a negative local minimum at z = R 50 , before increasing again, reaching zero at about the practical range z = Rp. In contrast, the signal from Al electrodes is shaped like the electron PDD(z) shape but with lower signal at the surface and higher bremsstrahlung tail. By subtracting the signal from Ta and Al electrodes we obtained a curve resembling PDD(z,E) after Bremsstrahlung contamination correction.
Conclusions: Multi-layer HEC sensors exhibit characteristic responses to electron beams that are unlike responses of ion chambers or diodes. Since the sensor structures are sensitive to electronic disequilibrium, high-Z electrodes give a signal proportional to the charge deposition pattern and can be modeled using the derivative of PDD(z).
(© 2024 American Association of Physicists in Medicine.)
Databáze: MEDLINE
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