Increased prevalence of the COVID-19 associated Neanderthal mutations in the Central European Roma population.

Autor: Hubáček JA; Experimental Medicine Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.; 3rd Department of Internal Medicine, 1st Faculty of Medicine, Charles University, Prague, Czech Republic., Šedová L; Faculty of Health and Social Sciences, University of South Bohemia, České Budějovice, Czech Republic., Hellerová V; Faculty of Health and Social Sciences, University of South Bohemia, České Budějovice, Czech Republic., Adámková V; Department of Preventive Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic., Tóthová V; Faculty of Health and Social Sciences, University of South Bohemia, České Budějovice, Czech Republic.
Jazyk: angličtina
Zdroj: Annals of human biology [Ann Hum Biol] 2024 Feb; Vol. 51 (1), pp. 2341727. Date of Electronic Publication: 2024 May 21.
DOI: 10.1080/03014460.2024.2341727
Abstrakt: Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and subsequent COVID-19 has spread world-wide and become pandemic with about 7 million deaths reported so far. Interethnic variability of the disease has been described, but a significant part of the differences remain unexplained and may be attributable to genetic factors.
Aim: To analyse genetic factors potentially influencing COVID-19 susceptibility and severity in European Roma minority.
Subjects and Methods: Two genetic determinants, within OAS-1 (2-prime,5-prime-oligoadenylate synthetase 1, a key protein in the defence against viral infection; it activates RNases that degrade viral RNAs; rs4767027 has been analysed) and LZTFL1 (leucine zipper transcription factor-like 1, expressed in the lung respiratory epithelium; rs35044562 has been analysed) genes were screened in a population-sample of Czech Roma ( N  = 302) and majority population ( N  = 2,559).
Results: For both polymorphisms, Roma subjects were more likely carriers of at least one risky allele for both rs4767027-C ( p  < 0.001) and rs35044562-G ( p  < 0.00001) polymorphism. There were only 5.3% Roma subjects without at least one risky allele in comparison with 10.1% in the majority population ( p  < 0.01).
Conclusions: It is possible that different genetic background plays an important role in increased prevalence of COVID-19 in the Roma minority.
Databáze: MEDLINE
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