Towards a comprehensive biomechanical assessment of the elderly combining in vivo data and in silico methods.
| Autor: | Davico G; Department of Industrial Engineering, Alma Mater Studiorum - University of Bologna, Bologna, Italy., Labanca L; Physical Medicine and Rehabilitation Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Gennarelli I; Department of Electronics and Telecommunications, Politecnico di Torino, Torino, Italy., Benedetti MG; Physical Medicine and Rehabilitation Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.; Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum - University of Bologna, Bologna, Italy., Viceconti M; Department of Industrial Engineering, Alma Mater Studiorum - University of Bologna, Bologna, Italy.; Medical Technology Lab, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in bioengineering and biotechnology [Front Bioeng Biotechnol] 2024 May 06; Vol. 12, pp. 1356417. Date of Electronic Publication: 2024 May 06 (Print Publication: 2024). |
| DOI: | 10.3389/fbioe.2024.1356417 |
| Abstrakt: | The aging process is commonly accompanied by a general or specific loss of muscle mass, force and/or function that inevitably impact on a person's quality of life. To date, various clinical tests and assessments are routinely performed to evaluate the biomechanical status of an individual, to support and inform the clinical management and decision-making process (e.g., to design a tailored rehabilitation program). However, these assessments (e.g., gait analysis or strength measures on a dynamometer) are typically conducted independently from one another or at different time points, providing clinicians with valuable yet fragmented information. We hereby describe a comprehensive protocol that combines both in vivo measurements (maximal voluntary isometric contraction test, superimposed neuromuscular electrical stimulation, electromyography, gait analysis, magnetic resonance imaging, and clinical measures) and in silico methods (musculoskeletal modeling and simulations) to enable the full characterization of an individual from the biomechanical standpoint. The protocol, which requires approximately 4 h and 30 min to be completed in all its parts, was tested on twenty healthy young participants and five elderlies, as a proof of concept. The implemented data processing and elaboration procedures allowing for the extraction of several biomechanical parameters (including muscle volumes and cross-sectional areas, muscle activation and co-contraction levels) are thoroughly described to enable replication. The main parameters extracted are reported as mean and standard deviation across the two populations, to highlight the potential of the proposed approach and show some preliminary findings (which were in agreement with previous literature). Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Davico, Labanca, Gennarelli, Benedetti and Viceconti.) |
| Databáze: | MEDLINE |
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