Contact sensitization and self-reported eczema in Swedish painters with occupational exposure to isothiazolinones.

Autor: Edlund M; Department of Occupational and Environmental Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Holm M; Department of Occupational and Environmental Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Inerot A; Department of Occupational and Environmental Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Långsved L; Department of Occupational and Environmental Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Dahlman-Höglund A; Department of Occupational and Environmental Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Hagvall L; Department of Occupational and Environmental Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Jazyk: angličtina
Zdroj: Contact dermatitis [Contact Dermatitis] 2024 Aug; Vol. 91 (2), pp. 126-132. Date of Electronic Publication: 2024 May 20.
DOI: 10.1111/cod.14572
Abstrakt: Background: Due to an increasing occupational usage of isothiazolinone (IT)-containing preservatives, and their potential to cause skin sensitization and allergic contact dermatitis, that is, chronic disease, there is a need for more knowledge on how highly exposed workers are affected.
Objectives: The overall objective was to explore dermatological symptoms of potentially long-lasting or chronic character in Swedish painters.
Methods: Building painters from western and southern Sweden were initially invited to perform a questionnaire on occurrence of skin symptoms. Participants with affirmative responses, and the right inclusion criteria, were further invited to patch testing with four different ITs: benzisothiazolinone (BIT), methylisothiazolinone, methylchloroisothiazolinone and octylisothiazolinone.
Results: There was a tendency towards higher occurrence of positive patch test reactions among the painters compared with occupationally unexposed registry patients; however, not statistically significant differences. BIT was the substance most frequently causing positive test results in both groups. The occurrence of adult-onset eczema was higher in painters than in the control group of electricians, and just shy of statistical significance concerning any of several skin locations (face/legs/arms/hands).
Conclusion: Building painters present with positive patch test reactions to common paint preservatives (ITs), and they report adult-onset eczema more often than do less occupationally exposed groups.
(© 2024 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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