Cytophagic histiocytic panniculitis leading to a diagnosis of acute myeloid leukemia with monocytic differentiation: A case report and literature review.

Autor: Arnoff TE; The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA., Mirza FN; Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA., Yumeen S; Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA., Ben Khadra S; Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.; Department of Pathology and Laboratory Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA., George DD; Hartford Healthcare Cancer Institute, Hartford, Connecticut, USA., Robinson-Bostom L; Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.; Department of Pathology and Laboratory Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Jazyk: angličtina
Zdroj: Journal of cutaneous pathology [J Cutan Pathol] 2024 Sep; Vol. 51 (9), pp. 658-661. Date of Electronic Publication: 2024 May 20.
DOI: 10.1111/cup.14659
Abstrakt: Cytophagic histiocytic panniculitis (CHP) is associated with a number of systemic conditions and is characterized by the presence of benign phagocytic histiocytes ("bean bag cells"), including phagocytosed erythrocytes, leukocytes, and platelets. We describe a case of a 72-year-old female who presented with a papular eruption that clinically mimicked pityriasis lichenoides et varioliformis acuta (PLEVA). Given that her skin biopsy had multiple features concerning PLEVA, this diagnosis was classified as a superficial pityriasis lichenoides-like variant of CHP. The histopathologic presence of cytophagic histiocytosis prompted workup for a systemic malignancy, leading to a diagnosis of underlying acute monocytic leukemia of myeloid lineage.
(© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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