Pregnancy outcomes in women with imported malaria in mainland France: A retrospective study from 2004 to 2014.

Autor: Imbert P; Service des maladies infectieuses et tropicales, Hôpital d'instruction des armées Bégin, 69 Avenue de Paris, 94160, Saint-Mandé, France., Nizard J; Service de gynécologie obstétrique, Hôpital Pitié-Salpêtrière, Assistance Publique des Hôpitaux de Paris, 47 Boulevard de L'Hôpital, 75013, Paris, France., Werkoff G; Service de gynécologie, Hôpital d'instruction des armées Bégin, 69 Avenue de Paris, 94160, Saint-Mandé, France., Kendjo E; Service de parasitologie-mycologie, Centre National de Référence du paludisme, Hôpital Pitié-Salpêtrière, Assistance Publique des Hôpitaux de Paris, 47 Boulevard de L'Hôpital, 75013, Paris, France., Ficko C; Service des maladies infectieuses et tropicales, Hôpital d'instruction des armées Bégin, 69 Avenue de Paris, 94160, Saint-Mandé, France., Thellier M; Service de parasitologie-mycologie, Centre National de Référence du paludisme, Hôpital Pitié-Salpêtrière, Assistance Publique des Hôpitaux de Paris, 47 Boulevard de L'Hôpital, 75013, Paris, France; UMRS 1136, Institut Pierre-Louis d'épidémiologie et de santé publique (IPLESP), Sorbonne Université, 27 Rue Chaligny, 75571, Paris 12, France; UPMC, Faculté de médecine, Sorbonne Université, Université Pierre-et-Marie-Curie, 91 Boulevard de l'Hôpital, 75013, Paris, France.
Jazyk: angličtina
Zdroj: Travel medicine and infectious disease [Travel Med Infect Dis] 2024 Jul-Aug; Vol. 60, pp. 102727. Date of Electronic Publication: 2024 May 19.
DOI: 10.1016/j.tmaid.2024.102727
Abstrakt: Objectives: There is little data on pregnant women with imported malaria in high-income countries, especially regarding offspring outcomes. We wanted to determine pregnancy outcomes of imported malaria in pregnant women in mainland France.
Patients and Methods: We conducted a retrospective, descriptive study of outcomes in pregnant women hospitalized with malaria from 2004 to 2014 in two regions of mainland France. An adverse outcome was defined as a miscarriage, stillbirth, preterm birth (<35 weeks of gestation), low birth weight (LBW) defined as less than 2500 g, or congenital malaria.
Results: Of 60 pregnancies, 5 were excluded because of elective abortions; 55 were investigated, of which 11 were primigravidae and 44 multigravidae. Pregnancies were singleton (n = 51) or twin (n = 4). Mean age was 30.4 years (range:19-45 y). Among the 55 cases, 9 ended in a miscarriage (8 singletons and 1 twin pregnancy) and 1 had a stillbirth at 21 weeks of gestation, all immediately after the malarial episode. 45 gave birth (29 vaginal deliveries and 16 caesarean sections) to 48 (42 singletons and 6 twins) newborns. Amongst these, 30 were healthy full-term newborns, 10 had LBW, and 8 were preterm. Overall, 26 of 55 (47.3%) pregnancies, and 29 of 59 (49.2%) offsprings had adverse outcomes. Compared to singleton pregnancies, twin pregnancies were associated with adverse outcomes (p = 0.0438).
Conclusions: Imported malaria has a severe impact on pregnancy outcomes. Prevention and management of imported malaria in pregnancy should be optimized.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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