Mechanisms of antibody mediated immunity - Distinct in early life.

Autor: Labeur-Iurman L; National Heart & Lung Institute, Imperial College London, London, United Kingdom. Electronic address: lucia.labeur-iurman18@imperial.ac.uk., Harker JA; National Heart & Lung Institute, Imperial College London, London, United Kingdom; Centre for Paediatrics and Child Health, Imperial College London, London, United Kingdom. Electronic address: j.harker@imperial.ac.uk.
Jazyk: angličtina
Zdroj: The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2024 Jul; Vol. 172, pp. 106588. Date of Electronic Publication: 2024 May 18.
DOI: 10.1016/j.biocel.2024.106588
Abstrakt: Immune responses in early life are characterized by a failure to robustly generate long-lasting protective responses against many common pathogens or upon vaccination. This is associated with a reduced ability to generate T-cell dependent high affinity antibodies. This review highlights the differences in T-cell dependent antibody responses observed between infants and adults, in particular focussing on the alterations in immune cell function that lead to reduced T follicular helper cell-B cell crosstalk within germinal centres in early life. Understanding the distinct functional characteristics of early life humoral immunity, and how these are regulated, will be critical in guiding age-appropriate immunological interventions in the very young.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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