Deciduous teeth from the New Hampshire birth cohort study: Early life environmental and dietary predictors of dentin elements.

Autor: Bauer JA; Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA; Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, Chicago, IL, USA. Electronic address: jnabauer@uic.edu., Punshon T; Department of Biological Sciences, Dartmouth College, Hanover, NH, USA., Barr MN; Department of Earth Sciences, Dartmouth College, Hanover, NH, USA., Jackson BP; Department of Earth Sciences, Dartmouth College, Hanover, NH, USA., Weisskopf MG; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Bidlack FB; The ADA-Forsyth Institute, Cambridge, MA, USA., Coker MO; Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA; Department of Oral Biology, School of Dental Medicine, Rutgers University, Newark, NJ, USA., Peacock JL; Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA., Karagas MR; Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA.
Jazyk: angličtina
Zdroj: Environmental research [Environ Res] 2024 Sep 01; Vol. 256, pp. 119170. Date of Electronic Publication: 2024 May 18.
DOI: 10.1016/j.envres.2024.119170
Abstrakt: Background: Sparse research exists on predictors of element concentrations measured in deciduous teeth.
Objective: To estimate associations between maternal/child characteristics, elements measured in home tap water during pregnancy and element concentrations in the dentin of shed deciduous teeth.
Methods: Our analysis included 152 pregnant person-infant dyads followed from the second trimester through the end of the first postnatal year from the New Hampshire Birth Cohort Study. During pregnancy and early infancy, we collected dietary and sociodemographic information via surveys, measured elements in home tap water, and later collected naturally exfoliated teeth from child participants. We measured longitudinal deposition of elements in dentin using LA-ICP-MS. Multivariable linear mixed models were used to estimate associations between predictors and dentin element concentrations.
Results: We measured 12 elements in dentin including those previously reported (Ba, Mn, Pb, Sr, Zn) and less frequently reported (Al, As, Cd, Cu, Hg, Li, and W). A doubling of Pb or Sr concentrations in water was associated with higher dentin Pb or Sr respectively in prenatally formed [9% (95%CI: 3%, 15%); 3% (1%, 6%)] and postnatally formed [10% (2%, 19%); 6% (2%, 10%)] dentin. Formula feeding from birth to 6 weeks or 6 weeks to 4 months was associated with higher element concentrations in postnatal dentin within the given time period as compared to exclusive human milk feeding: Sr: 6 weeks: 61% (36%, 90%) and 4 months: 85% (54%, 121%); Ba: 6 weeks: 35% (3.3%, 77%) and 4 months: 42% (10%, 83%); and Li: 6 weeks: 61% (33%, 95%) and 4 months: 58% (31%, 90%).
Significance: These findings offer insights into predictors of dentin elements and potential confounders in exposure-health outcome relationships during critical developmental periods.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: