Decontamination of Actinide-contaminated Injured Skin with Ca-DTPA Products Using an Ex Vivo Rat Skin Model.

Autor:	Van der Meeren A; Laboratory of Radio Toxicology, CEA, Paris-Saclay University, 91297 Arpajon, France., Devilliers K; Laboratory of Radio Toxicology, CEA, Paris-Saclay University, 91297 Arpajon, France., Griffiths N; Laboratory of Radio Toxicology, CEA, Paris-Saclay University, 91297 Arpajon, France., Chaplault AS; Laboratory of Radio Toxicology, CEA, Paris-Saclay University, 91297 Arpajon, France., Defrance M; Laboratory of Radio Toxicology, CEA, Paris-Saclay University, 91297 Arpajon, France., Ducouret G, Pasteur M; Pharmacie Centrale des Armées, Fleury les Aubrais, France., Laroche P; Direction of Health, Security, Environment & Radioprotection, Orano, Châtillon, France., Caire-Maurisier F; Pharmacie Centrale des Armées, Fleury les Aubrais, France.
Jazyk:	angličtina
Zdroj:	Health physics [Health Phys] 2024 Oct 01; Vol. 127 (4), pp. 490-503. Date of Electronic Publication: 2024 May 17.
DOI:	10.1097/HP.0000000000001827
Abstrakt:	Abstract: Skin contamination by α-emitting actinides such as plutonium and americium is a risk for workers during nuclear fuel production and reactor decommissioning. Decontamination of skin is an important medical countermeasure to limit potential internal contamination, particularly in the case of injured skin. Current recommendations include undressing of the victim followed by skin washing using soap or chelating agents, such as diethylene triamine pentaacetic acid (DTPA). The goal of the present work is to assess the efficacy of a novel Ca-DTPA loaded gel to decontaminate injured skin exposed to plutonium or americium as compared to recommended treatments. For decontaminant testing on injured skin, whole body skin was obtained from euthanized rats and lesions created using a metallic brush. Delimited test areas were contaminated with plutonium or americium solutions of known properties. Various protocols were tested including time before contamination, duration of gel application, washing steps, as well as the concomitant addition or not of dressings. Activity was measured in each decontamination product and in skin. Data indicate that healthy skin was easier to decontaminate than damaged skin. On injured skin, we demonstrated an increased decontamination efficacy of the Ca-DTPA gel formulation as compared to the solution. Importantly, gel application alone was effective, and further gel applications could be used for residual activity. (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Health Physics Society.)
Databáze:	MEDLINE
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