Infectious hepatitis E virus is associated with the mature sperm head.

Autor: Yadav KK; Center for Food Animal Health, Department of Animal Sciences, The Ohio State University, Wooster, Ohio, United States of America.; Department of Veterinary Preventive Medicine, The Ohio State University, College of Veterinary Medicine, Columbus, Ohio, United States of America., Boley PA; Center for Food Animal Health, Department of Animal Sciences, The Ohio State University, Wooster, Ohio, United States of America., Laocharoensuk T; Center for Food Animal Health, Department of Animal Sciences, The Ohio State University, Wooster, Ohio, United States of America.; Department of Veterinary Preventive Medicine, The Ohio State University, College of Veterinary Medicine, Columbus, Ohio, United States of America., Khatiwada S; Center for Food Animal Health, Department of Animal Sciences, The Ohio State University, Wooster, Ohio, United States of America., Lee CM; Center for Food Animal Health, Department of Animal Sciences, The Ohio State University, Wooster, Ohio, United States of America.; Department of Veterinary Preventive Medicine, The Ohio State University, College of Veterinary Medicine, Columbus, Ohio, United States of America., Bhandari M; Center for Food Animal Health, Department of Animal Sciences, The Ohio State University, Wooster, Ohio, United States of America., Moore L; The College of Wooster, Wooster, Ohio, United States of America., Hanson J; Center for Food Animal Health, Department of Animal Sciences, The Ohio State University, Wooster, Ohio, United States of America.; Plant and Animal Agrosecurity Research Facility, Center for Food Animal Health, Department of Animal Sciences, The Ohio State University, Wooster, Ohio, United States of America., Kenney SP; Center for Food Animal Health, Department of Animal Sciences, The Ohio State University, Wooster, Ohio, United States of America.; Department of Veterinary Preventive Medicine, The Ohio State University, College of Veterinary Medicine, Columbus, Ohio, United States of America.
Jazyk: angličtina
Zdroj: PLoS pathogens [PLoS Pathog] 2024 May 20; Vol. 20 (5), pp. e1012240. Date of Electronic Publication: 2024 May 20 (Print Publication: 2024).
DOI: 10.1371/journal.ppat.1012240
Abstrakt: Hepatitis E virus (HEV) is the leading cause of acute viral hepatitis worldwide. HEV associated pregnancy mortality has been reported as up to 30% in humans. Recent findings suggest HEV may elicit effects directly in the reproductive system with HEV protein found in the testis, viral RNA in semen, and viral replication occurring in placental cell types. Using a natural host model for HEV infection, pigs, we demonstrate infectious HEV within the mature spermatozoa and altered sperm viability from HEV infected pigs. HEV isolated from sperm remained infectious suggesting a potential transmission route via sexual partners. Our findings suggest that HEV should be explored as a possible sexually transmittable disease. Our findings propose that infection routes outside of oral and intravenous infection need to be considered for their potential to contribute to higher mortality in HEV infections when pregnancy is involved and in HEV disease in general.
Competing Interests: The authors declare no conflict of interest.
(Copyright: © 2024 Yadav et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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