Association of the pre-transplant CD4/CD8 ratio with the prognosis following allogeneic hematopoietic stem cell transplantation.

Autor: Nagayama T; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan.; Division of Cell Transplantation and Transfusion, Jichi Medical University Hospital, Tochigi, Japan., Fujiwara SI; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan.; Division of Cell Transplantation and Transfusion, Jichi Medical University Hospital, Tochigi, Japan., Tominaga R; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan., Yokoyama D; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan., Noguchi A; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan., Furuki S; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan., Oyama T; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan., Koyama S; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan., Murahashi R; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan., Nakashima H; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan., Ikeda T; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan., Hyodo K; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan., Kawaguchi SI; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan., Toda Y; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan., Umino K; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan., Minakata D; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan., Morita K; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan., Ashizawa M; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan., Yamamoto C; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan., Hatano K; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan., Sato K; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan., Ohmine K; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan., Kanda Y; Division of Hematology, Department of Medicine, Jichi Medical University, Tochigi, Japan.
Jazyk: angličtina
Zdroj: Leukemia & lymphoma [Leuk Lymphoma] 2024 Sep; Vol. 65 (9), pp. 1350-1356. Date of Electronic Publication: 2024 May 20.
DOI: 10.1080/10428194.2024.2352614
Abstrakt: The tumor microenvironment's cells can promote or inhibit tumor formation, and there are no reports on the CD4/CD8 ratio's association with outcomes post allogeneic hematopoietic stem cell transplantation (allo-HSCT). We retrospectively evaluated the pre-transplant peripheral blood CD4/CD8 ratio in 168 patients who underwent their first allo-HSCT for hematological malignancies at our institution. When patients were divided into two groups according to the median CD4/CD8 ratio 1.35 (range, 0.09-19.89), the high CD4/CD8 ratio group had a higher incidence of relapse, equivalent non-relapse mortality and worse overall survival (OS) than the low CD4/CD8 ratio group. In a multivariate analysis, the CD4/CD8 ratio was significantly associated with an increased risk of relapse, although there was a marginally significant difference in OS. The pre-transplant peripheral blood CD4/CD8 ratio could be a novel biomarker for predicting the prognosis of allo-HSCT.
Databáze: MEDLINE