Gemcitabine-Induced Myonecrosis Following Hypofractionated Radiation.
| Autor: | Ben-David MA; Department of Oncology, Assuta Medical Center, Tel Aviv, ISR.; Faculty of Health Sciences, Ben Gurion University, Beer-Sheva, ISR., Schwartz I; Department of Pathology, Sheba Medical Center, Ramat Gan, ISR., Eshed I; Department of Diagnostic Imaging, Sheba Medical Center, Ramat Gan, ISR.; School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, ISR., Levanon K; School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, ISR.; The Jusidman Cancer Center, Sheba Medical Center, Ramat Gan, ISR. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 Apr 19; Vol. 16 (4), pp. e58591. Date of Electronic Publication: 2024 Apr 19 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.58591 |
| Abstrakt: | Palliative radiation is often used to abate pain and prevent bone fractures in patients with metastatic cancer. Hypofractionation, meaning delivery of larger doses of radiation in each treatment session (fraction), has become the standard of care in most cases. It not only reduces the burden on the medical system and facilitates the relief of symptoms but also enables the maintenance of the continuity of systemic therapy. Radiation recall phenomenon (RRP) is an acute inflammatory reaction in previously irradiated tissues that is provoked by chemotherapeutic drug administration. The incidence, severity, and prognosis of RRP following hypofractionated radiation therapy have not been studied. The symptoms of RRP depend on the radiation field, with the greatest concern associated with mucosal and dermal damage, though other symptoms have also been reported. Here, we describe a case of a 41-year-old woman with metastatic breast cancer (hormone receptor-positive, HER2/neu negative), who received palliative radiation to four other fields along the course of her disease, before her presentation with isolated myonecrosis of the thigh muscles. This RRP occurred four months following the last of two fractions of 8 Gy radiation to this region, given three months apart, and after six courses of cisplatin + gemcitabine. The symptoms improved with cessation of gemcitabine and prolonged administration of non-steroidal anti-inflammatory medications. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2024, Ben-David et al.) |
| Databáze: | MEDLINE |
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