| Autor: |
Li YF; State Key Laboratory of Proteomics, National Center for Protein Sciences at Beijing, Beijing Institute of Radiation Medicine, Beijing 100850, China.; College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China., Wu TZ; Guangxi Medical University Cancer Hospital, Nanning 530021, China., Chen SQ; College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China., Wang YT; College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China., Zeng T; Medical School of Chinese PLA, Beijing 100853, China.; Faculty of Hepato-Pancreato-Biliary Surgery, First Medical Center, Chinese PLA General Hospital, Beijing 100853, China., Li RF; Medical School of Chinese PLA, Beijing 100853, China.; Faculty of Hepato-Pancreato-Biliary Surgery, First Medical Center, Chinese PLA General Hospital, Beijing 100853, China., Zhou GQ; State Key Laboratory of Proteomics, National Center for Protein Sciences at Beijing, Beijing Institute of Radiation Medicine, Beijing 100850, China.; Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China. |
| Abstrakt: |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes a broad clinical spectrum of coronavirus disease 2019 (COVID-19). Genetic factors might influence susceptibility to the SARS-CoV-2 infection or disease severity. Genome-wide association studies (GWASs) have identified multiple susceptible genes related to COVID-19 phenotypes, providing the scientific basis for the COVID-19 prevention and treatment. In this review, we summarize the recent progresses of COVID-19 susceptible genes, including the GWASs on multiple phenotypes of COVID-19, GWASs of COVID-19 in multiple ethnic populations, GWASs of COVID-19 based on multiple types of genetic variations, and the fine-mapping of the regions surrounding the susceptible genes. |
