Prognostic factors and overall survival of breast cancer in Benin: a hospital-based study.

Autor: Gnangnon FHR; Laboratory of Epidemiology of Chronic and Neurological Diseases, Lemacen, Cotonou, Benin. fredgnang@yahoo.fr.; Department of Visceral Surgery, National Teaching Hospital-Hubert Koutoukou Maga, CNHU-HKM, Cotonou, Benin. fredgnang@yahoo.fr.; EpiMaCT - Epidemiology of chronic diseases in tropical zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Inserm U1094, IRD U270, Univ. Limoges, CHU Limoges, Limoges, France. fredgnang@yahoo.fr.; Department of Surgical Oncology, Faculty of Health Sciences - University of Abomey-Calavi, Cotonou, Benin. fredgnang@yahoo.fr., Parenté A; Laboratory of Epidemiology of Chronic and Neurological Diseases, Lemacen, Cotonou, Benin.; EpiMaCT - Epidemiology of chronic diseases in tropical zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Inserm U1094, IRD U270, Univ. Limoges, CHU Limoges, Limoges, France., Aboubakar M; Department of Gynecological Obstetrics, National Teaching Hospital-Hubert Koutoukou Maga, CNHU-HKM, Cotonou, Benin., Kiki-Migan Y; Laboratory of Epidemiology of Chronic and Neurological Diseases, Lemacen, Cotonou, Benin., Totah T; Laboratory of Epidemiology of Chronic and Neurological Diseases, Lemacen, Cotonou, Benin., Gbessi DG; Department of Visceral Surgery, National Teaching Hospital-Hubert Koutoukou Maga, CNHU-HKM, Cotonou, Benin., Tonato-Bagnan JA; Lagoon Mother and Child University Hospital, CHU-MEL, Cotonou, Benin., Laleye A; Laboratory of Histology, Reproductive Biology, Cytogenetics and Medical Genetics, Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Benin., Preux PM; EpiMaCT - Epidemiology of chronic diseases in tropical zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Inserm U1094, IRD U270, Univ. Limoges, CHU Limoges, Limoges, France., Denakpo JL; Department of Gynecological Obstetrics, National Teaching Hospital-Hubert Koutoukou Maga, CNHU-HKM, Cotonou, Benin., Blanquet V; EpiMaCT - Epidemiology of chronic diseases in tropical zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Inserm U1094, IRD U270, Univ. Limoges, CHU Limoges, Limoges, France., Houinato DS; Laboratory of Epidemiology of Chronic and Neurological Diseases, Lemacen, Cotonou, Benin.; EpiMaCT - Epidemiology of chronic diseases in tropical zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Inserm U1094, IRD U270, Univ. Limoges, CHU Limoges, Limoges, France.
Jazyk: angličtina
Zdroj: BMC women's health [BMC Womens Health] 2024 May 18; Vol. 24 (1), pp. 295. Date of Electronic Publication: 2024 May 18.
DOI: 10.1186/s12905-024-03114-y
Abstrakt: Background: In Benin, a country in West Africa, breast cancer is the leading cancer in women, both in terms of incidence and mortality. However, evidence on the mortality of breast cancer and its associated factors is lacking in this country. Our aim was to describe and analyze the clinical, histopathological, and prognostic aspects of breast cancer in Benin.
Methods: A descriptive and analytical study was carried out at the CNHU-HKM and the CHU-MEL, two major tertiary referral hospitals for breast cancer management located in Cotonou, the capital city of Benin. All breast cancer medical records with histological evidence and immunohistochemistry studies were retrospectively collected between January 1, 2014, and September 30, 2020, in these two tertiary referral hospitals and analyzed in the current study.
Results: Finally, 319 medical records were included. The mean age at diagnosis was 48.74 years. The tumors were most frequently classified as T4 (47.6%) with lymph node involvement N2 (34.5%), and metastases were clinically noted in 21.9% of cases. Stage was reported in the medical records of 284 patients. Tumors were diagnosed at very late AJCC stages: stage III (47.5%) and stage IV (24.7%). Grades SBR 2 (49.2%) and SBR 3 (32.6%) were the most frequent grades. Triple-negative breast cancer (31.3%) was the most common molecular type. The overall 5-year survival was 48.49%. In multivariable analysis, the poor prognostic factors were lymph node invasion (HR = 2.63; p = 0.026; CI: [1.12, 6.17]), the presence of metastasis (HR = 3.64; p < 0.001); CI: [2.36, 5.62] and the immunohistochemical profile (HR = 1.29; p < 0.001; CI: [1.13, 1.48]).
Conclusions: Breast cancer in Beninese is predominant in young adults and is often diagnosed at a late stage. The survival of breast cancer patients in Benin can be improved by enhancing early diagnosis and multidisciplinary management.
(© 2024. The Author(s).)
Databáze: MEDLINE
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