NEUT-RI, a surrogate marker of NETosis is lower in patients with strong IgM antiphospholipid antibodies.

Autor: Bouvier S; Department of Hematology, Nîmes University Hospital, Place du Professeur Robert Debré, Nîmes, 30029, France. sylvie.bouvier@chu-nimes.fr.; Desbrest Institute of Epidemiology and Public Health, Univ Montpellier, INSERM, University of Montpellier, Montpellier, France. sylvie.bouvier@chu-nimes.fr.; Faculty of Pharmaceutical and Biological Sciences, University of Montpellier, Montpellier, France. sylvie.bouvier@chu-nimes.fr., Fortier M; Department of Hematology, Nîmes University Hospital, Place du Professeur Robert Debré, Nîmes, 30029, France., Nouvellon E; Department of Hematology, Nîmes University Hospital, Place du Professeur Robert Debré, Nîmes, 30029, France.; Desbrest Institute of Epidemiology and Public Health, Univ Montpellier, INSERM, University of Montpellier, Montpellier, France., Olivan A; Department of Hematology, Nîmes University Hospital, Place du Professeur Robert Debré, Nîmes, 30029, France., Chéa M; Department of Hematology, Nîmes University Hospital, Place du Professeur Robert Debré, Nîmes, 30029, France.; Desbrest Institute of Epidemiology and Public Health, Univ Montpellier, INSERM, University of Montpellier, Montpellier, France., Gris JC; Department of Hematology, Nîmes University Hospital, Place du Professeur Robert Debré, Nîmes, 30029, France.; Desbrest Institute of Epidemiology and Public Health, Univ Montpellier, INSERM, University of Montpellier, Montpellier, France.; Faculty of Pharmaceutical and Biological Sciences, University of Montpellier, Montpellier, France.; I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
Jazyk: angličtina
Zdroj: Journal of thrombosis and thrombolysis [J Thromb Thrombolysis] 2024 Aug; Vol. 57 (6), pp. 1051-1055. Date of Electronic Publication: 2024 May 18.
DOI: 10.1007/s11239-024-03001-1
Abstrakt: Background: Antiphospholipid antibody syndrome (APS) is an acquired autoimmune disorder characterized by recurrent venous or arterial thrombosis and/or pregnancy complications. Recently, thrombotic APS was linked to increased neutrophil extracellular traps (NET) formation, suggesting an association between NETs and the severity of APS-related thrombosis.
Methods: We performed a retrospective study on patients tested for presence of antiphospholipid antibodies (990 negative and 374 positive) to evaluate the association between the neutrophil activation state, estimated by the neutrophil reactive index (NEU-RI), a parameter routinely available from some haematology analysers, and antiphospholipid antibodies.
Results: We do not observe a difference in NEU-RI values between positive and negative patients globally. However, interestingly, we highlight an association between high titers of IgM and low NEU-RI values indicating a lower neutrophil activation.
Conclusion: Our data are in line with the recent questioning about the putative clinical consistency of positive solid-phase aPL IgM.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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