Amygdala volumes and associations with socio-emotional competencies in preterm youth: cross-sectional and longitudinal data.

Autor: Pereira Camejo M; Division of Development and Growth, Department of Paediatrics, Gynaecology and Obstetrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland., Escobar Saade L; Division of Development and Growth, Department of Paediatrics, Gynaecology and Obstetrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland., Liverani MC; SensoriMotor, Affective and Social Development Laboratory, Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland., Fischi-Gomez E; Centre for Biomedical Imaging (CIBM), SP CHUV-EPFL Section, Lausanne, Switzerland.; Signal processing laboratory 5, Ecole polytechnique fédérale de Lausanne, Geneva, Switzerland.; Department of Radiology, University Hospital and University of Lausanne, Lausanne, Switzerland., Gui L; Division of Development and Growth, Department of Paediatrics, Gynaecology and Obstetrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland., Borradori Tolsa C; Division of Development and Growth, Department of Paediatrics, Gynaecology and Obstetrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland., Ha-Vinh Leuchter R; Division of Development and Growth, Department of Paediatrics, Gynaecology and Obstetrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland., Hüppi PS; Division of Development and Growth, Department of Paediatrics, Gynaecology and Obstetrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland., Siffredi V; Division of Development and Growth, Department of Paediatrics, Gynaecology and Obstetrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland. Vanessa.Siffredi@unige.ch.; Neuro-X Institute, Ecole polytechnique fédérale de Lausanne, Geneva, Switzerland. Vanessa.Siffredi@unige.ch.; Department of Radiology and Medical Informatics, Faculty of Medicine, University of Geneva, Geneva, Switzerland. Vanessa.Siffredi@unige.ch.; Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Vanessa.Siffredi@unige.ch.
Jazyk: angličtina
Zdroj: Pediatric research [Pediatr Res] 2024 May 18. Date of Electronic Publication: 2024 May 18.
DOI: 10.1038/s41390-024-03227-y
Abstrakt: Background: Socio-emotional difficulties often result from very preterm (VPT) birth. The amygdala's developmental trajectory, including its nuclei, has been recognized as a significant factor in observed difficulties. This study aims to assess the relationship between amygdala volume and socio-emotional competencies in VPT children and adolescents.
Methods: Socio-emotional competencies were assessed, and amygdala volumes, including subnuclei, were extracted automatically from structural scans in a cross-sectional cohort of VPT (n = 75) and full-term (FT, n = 41) aged 6-14 years. Group differences in amygdala volumes were assessed using ANCOVA, and associations with socio-emotional competencies were studied using partial least squares correlation (PLSC). In a VPT subgroup, additional longitudinal data with amygdala volumes at term-equivalent age (TEA) were manually extracted, growth rates calculated, and associations with school-age socio-emotional competencies investigated using PLSC.
Results: Using cross-sectional data at school-age, amygdala volumes displayed comparable developmental patterns between the VPT and the FT groups. Greater volumes were associated with more emotional regulation difficulties in VPT and lower affect recognition competencies in FT. In the longitudinal VPT subgroup, no significant associations were found between amygdala volume trajectory and socio-emotional competencies.
Conclusion: Although our findings suggest typical amygdala development after VPT birth, further research is necessary to elucidate the developmental trajectory of amygdala and the role of resilience factors.
Impact: In our cohort, amygdala volumes, including subnuclei, displayed comparable developmental trajectories between the very preterm and the full-term groups. Higher amygdala volumes at school-age were associated with higher emotional regulation difficulties in the very-preterm born group, and with lower affect recognition abilities in full-term born children and adolescents. In a subgroup of very-preterm children and adolescents followed from birth to school-age, no significant associations were found between amygdala volumes at term-equivalent age and socio-emotional competencies at school-age.
(© 2024. The Author(s).)
Databáze: MEDLINE
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