Childhood adversity, accelerated GrimAge, and associated health consequences.

Autor: Harvanek ZM; Department of Psychiatry, Yale University, New Haven, CT, USA. Zachary.Harvanek@Yale.edu.; Yale Stress Center, Yale University, New Haven, CT, USA. Zachary.Harvanek@Yale.edu., Kudinova AY; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA.; Bradley Hospital, Providence, RI, USA., Wong SA; New York University Grossman School of Medicine, New York, USA., Xu K; Department of Psychiatry, Yale University, New Haven, CT, USA.; Department of Psychiatry, Connecticut Veteran Healthcare System, West Haven, CT, USA., Brick L; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA., Daniels TE; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA.; Bradley Hospital, Providence, RI, USA.; Initiative for Stress, Trauma, and Resilience, Alpert Medical School of Brown University, Providence, RI, USA.; Laboratory for Clinical and Translational Neuroscience, Butler Hospital, Providence, RI, USA., Marsit C; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Burt A; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Sinha R; Department of Psychiatry, Yale University, New Haven, CT, USA.; Yale Stress Center, Yale University, New Haven, CT, USA.; Department of Neuroscience, Yale University, New Haven, CT, USA.; Child Study Center, Yale University, New Haven, CT, USA., Tyrka AR; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA.; Initiative for Stress, Trauma, and Resilience, Alpert Medical School of Brown University, Providence, RI, USA.; Laboratory for Clinical and Translational Neuroscience, Butler Hospital, Providence, RI, USA.
Jazyk: angličtina
Zdroj: Journal of behavioral medicine [J Behav Med] 2024 Oct; Vol. 47 (5), pp. 913-926. Date of Electronic Publication: 2024 May 18.
DOI: 10.1007/s10865-024-00496-0
Abstrakt: Childhood adversity is linked to psychological, behavioral, and physical health problems, including obesity and cardiometabolic disease. Epigenetic alterations are one pathway through which the effects of early life stress and adversity might persist into adulthood. Epigenetic mechanisms have also been proposed to explain why cardiometabolic health can vary greatly between individuals with similar Body Mass Index (BMIs). We evaluated two independent cross-sectional cohorts of adults without known medical illness, one of which explicitly recruited individuals with early life stress (ELS) and control participants (n = 195), and the other a general community sample (n = 477). In these cohorts, we examine associations between childhood adversity, epigenetic aging, and metabolic health. Childhood adversity was associated with increased GrimAge Acceleration (GAA) in both cohorts, both utilizing a dichotomous yes/no classification (both p < 0.01) as well as a continuous measure using the Childhood Trauma Questionnaire (CTQ) (both p < 0.05). Further investigation demonstrated that CTQ subscales for physical and sexual abuse (both p < 0.05) were associated with increased GAA in both cohorts, whereas physical and emotional neglect were not. In both cohorts, higher CTQ was also associated with higher BMI and increased insulin resistance (both p < 0.05). Finally, we demonstrate a moderating effect of BMI on the relationship between GAA and insulin resistance where GAA correlated with insulin resistance specifically at higher BMIs. These results, which were largely replicated between two independent cohorts, suggest that interactions between epigenetics, obesity, and metabolic health may be important mechanisms through which childhood adversity contributes to long-term physical and metabolic health effects.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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