Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types.

Autor: Faget L; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA. lfaget@health.ucsd.edu.; Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA. lfaget@health.ucsd.edu., Oriol L; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA., Lee WC; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA., Zell V; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA., Sargent C; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA., Flores A; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.; Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA., Hollon NG; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA., Ramanathan D; Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA., Hnasko TS; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA. thnasko@health.ucsd.edu.; Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA. thnasko@health.ucsd.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 May 18; Vol. 15 (1), pp. 4233. Date of Electronic Publication: 2024 May 18.
DOI: 10.1038/s41467-024-48340-y
Abstrakt: The ventral pallidum (VP) contains GABA and glutamate neurons projecting to ventral tegmental area (VTA) whose stimulation drives approach and avoidance, respectively. Yet little is known about the mechanisms by which VP cell types shape VTA activity and drive behavior. Here, we found that both VP GABA and glutamate neurons were activated during approach to reward or by delivery of an aversive stimulus. Stimulation of VP GABA neurons inhibited VTA GABA, but activated dopamine and glutamate neurons. Remarkably, stimulation-evoked activation was behavior-contingent such that VTA recruitment was inhibited when evoked by the subject's own action. Conversely, VP glutamate neurons activated VTA GABA, as well as dopamine and glutamate neurons, despite driving aversion. However, VP glutamate neurons evoked dopamine in aversion-associated ventromedial nucleus accumbens (NAc), but reduced dopamine release in reward-associated dorsomedial NAc. These findings show how heterogeneous VP projections to VTA can be engaged to shape approach and avoidance behaviors.
(© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
Databáze: MEDLINE
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